Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
about
Melanoma: from melanocyte to genetic alterations and clinical optionsThe guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cellsDirect binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activationMelanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cellsRoles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceDifferential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanismsConstitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosisPreponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastasesThe Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin CancerCellular and Molecular Responses to Mechanical Expansion of TissueA CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2Trihydrophobin 1 is a new negative regulator of A-Raf kinaseB-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouseStimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cellsRap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activationUpregulation and maintenance of gap junctional communication in lens cellscAMP analogs and their metabolites enhance TREK-1 mRNA and K+ current expression in adrenocortical cells.p38 regulates pigmentation via proteasomal degradation of tyrosinase.Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformationACTH induces Cav3.2 current and mRNA by cAMP-dependent and cAMP-independent mechanisms.Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathwaysGalpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a).High frequency of BRAF mutations in nevi.Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuitValidation of the VE1 immunostain for the BRAF V600E mutation in melanoma.Skin phototype: a new perspective.Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT.Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.Melanocortin MC₁ receptor in human genetics and model systems.Follicle-stimulating hormone activates extracellular signal-regulated kinase but not extracellular signal-regulated kinase kinase through a 100-kDa phosphotyrosine phosphataseDopaminergic tone regulates transient potassium current maximal conductance through a translational mechanism requiring D1Rs, cAMP/PKA, Erk and mTOR.Carney complex and lentiginosisMicrophthalamia-associated transcription factor: a critical regulator of pigment cell development and survival.Ultraviolet radiation and cutaneous malignant melanoma.Search for new cyclic AMP-binding proteins.Potential Leydig cell mitogenic signals generated by the wild-type and constitutively active mutants of the lutropin/choriogonadotropin receptor (LHR).BRAF and NRAS mutations are uncommon in melanomas arising in diverse internal organs.
P2860
Q21284811-102F4E00-D245-4531-9633-A7599E605D35Q24293716-248D70CA-085F-45D4-ABA1-97480463652AQ24311922-87C09929-8725-4B47-A7DD-FD2CE6CD0BBDQ24316155-92896A92-7821-4E28-9411-47CD1EB22E20Q24645668-26662488-73C5-4C9D-86D2-406A9ABC5F80Q24674150-6882191F-186B-4427-92C4-F6BFABBABDE6Q24791830-B83F078B-2722-4F31-9CFD-11DAA4858F96Q24814098-AFD1DA8A-5EF6-4CE4-9B25-36F696940CF0Q26747247-D981AB7A-85ED-47A7-BED0-3BD8CDEA43D5Q28066405-43E20CFF-510D-4E2D-8B52-DC965168B892Q28211197-E6A3EE06-95BA-4107-BCA0-4A883A5FDBE0Q28235129-5BE9DA7D-C0CE-4CB9-A52E-5210C7CFDB81Q28476616-89C29B32-5C7D-488F-8CD4-2D4E1CD33A23Q28513370-2EF614A6-E39E-4DC8-A917-CEF29B2E1F1DQ28584307-880F610C-84F3-4AEB-A7C3-DD31D9CE3BFDQ28752600-CDAC149A-D73A-4B2C-96EA-58922C3089D0Q33714698-635DF45F-F751-47E4-B493-39ED126D0761Q33748070-1AA778E4-5697-4FE0-9760-7A98CF431F05Q33786919-A29FC946-3D84-4A00-BBA9-1ABD212B8F4DQ33924353-4C7F243C-E0B6-44A0-8E71-DDFA2C55EA2FQ33966221-163499C9-9927-452D-9D75-289500A95684Q33967880-7C7A2E26-F186-45B5-873C-BEE33903E0F4Q34148749-07CCBD49-78B1-4FEF-BA91-D0988F515171Q34160428-62E03B4B-C8BA-45C8-A6DF-CF6092078878Q34160519-7AF4F325-A331-4406-9A01-2B49C141F5BAQ34206033-6F85B719-178A-4ECC-B3B3-1CAC29FA0109Q34207132-22BA83CC-1371-429E-8AD1-C598BBA3DFB7Q34467780-DE9F6D68-B63D-4EA0-ADE7-5F9C4ECD4B9EQ34943036-A08798E0-5F8E-4C97-9FFA-578A4495ABE9Q34966603-C7991A84-ED40-4610-8E23-FD8321C70301Q34973413-1C53C871-B610-4ABE-BCFB-9C1F5942811DQ34984641-FB80E3FA-AFDD-4208-B483-C01C1F6BEA71Q35024993-BB59E41C-086D-46B7-9FE4-1DDF864CB997Q35041795-8746BF56-F6BE-4223-9EA3-CEBD3D1E3026Q35106673-39A5B632-FCEC-4966-8F78-FC0E170841A3Q35146535-07B17893-F697-4B4D-8E12-D87564FE4E8FQ35146567-79D03A4D-8DA8-4A36-9171-131B346524C0Q35163961-C8EE0155-BA1E-4AB4-AB03-09C98745BEDDQ35567393-B5B5D524-26C3-4AB8-8ED0-3869C2A5F1B4Q35588657-4021A5FC-66C0-475D-BF12-7E57C6E819EB
P2860
Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Ras mediates the cAMP-dependen ...... kinases (ERKs) in melanocytes
@en
Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases
@nl
type
label
Ras mediates the cAMP-dependen ...... kinases (ERKs) in melanocytes
@en
Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases
@nl
prefLabel
Ras mediates the cAMP-dependen ...... kinases (ERKs) in melanocytes
@en
Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases
@nl
P2093
P2860
P356
P1433
P1476
Ras mediates the cAMP-dependen ...... kinases (ERKs) in melanocytes
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/19.12.2900
P407
P577
2000-06-01T00:00:00Z