Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.
about
Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatBCrystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma bruceiIn Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruziMining a cathepsin inhibitor library for new antiparasitic drug leadsQuantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol proteaseAutomated high-throughput system to fractionate plant natural products for drug discovery.Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness.Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin.A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moietySynthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.Host-parasite interactions in trypanosomiasis: on the way to an antidisease strategy.Development of protease inhibitors for protozoan infections.Structure-guided development of selective TbcatB inhibitorsTrypanocidal drugs: mechanisms, resistance and new targets.Chemoinformatic analysis as a tool for prioritization of trypanocidal marine derived lead compounds.Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug effluxState of the art in African trypanosome drug discovery.Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatBSynthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones.Antimalarial activity of thiosemicarbazones and purine derived nitriles.Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes.Rational Selection of Anti-Microbial Drug Targets: Unique or Conserved?
P2860
Q27658146-457A6B41-CAE6-43DA-A579-926880999012Q27662211-C5AA1E1D-D151-43FD-A70C-89FCBC5DD7D3Q27664609-2DE39974-F961-4833-97D8-F27EF3E3093CQ28478016-62D38393-F4CC-464C-936B-5F0190405183Q30883378-C66B8731-E14C-47A1-8A7D-CACD57586030Q33541158-4E28DC3F-2A18-4B19-B6B4-42D1DC53A77CQ33543529-5E532BDA-2A90-42FF-BEDA-D6CD246602F0Q33893778-29D4CB6B-1E7A-42AC-AB72-5484091E6F9FQ34363517-096A2A94-EBEB-46C8-8E68-4EEC711F9ABEQ34707912-39887293-1A4C-4740-821A-6D8EE329CAC6Q36122310-A2B08FDE-5412-4DC3-A7B6-4698F80184B5Q37145013-534BF18C-C38A-4243-B34D-A664E5C2F11FQ37315245-525FEE7A-F8F7-4817-A969-549B19FD1E2EQ37388725-B8681F3B-A72A-4789-BEA3-18803AA97D9EQ37623081-10FB6535-CE04-45BD-98D9-FF7D137E4AA8Q37666958-7ABD7110-9B19-47D6-9F6B-ABDDA7CD838FQ37679508-2423DE43-210C-4BC0-B874-8032F825162DQ37852737-752DF5A7-9AAD-4C35-A20A-B94FCBF5DCA1Q39412077-5CD5E5EA-E87B-46AE-9F47-379DA8D273A3Q39627889-25138006-A291-45B9-BBA8-EFAD9DF5C589Q41938383-2AB6A004-9C84-436B-86E2-3B6D5DF882D8Q42362343-71B37274-1E8A-45E2-8C54-675A2F568126Q58850854-BE6F3AFD-16B3-450B-9246-129F77FF1640
P2860
Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Development of potent purine-d ...... trypanosomal protease TbcatB.
@en
type
label
Development of potent purine-d ...... trypanosomal protease TbcatB.
@en
prefLabel
Development of potent purine-d ...... trypanosomal protease TbcatB.
@en
P2093
P356
P1476
Development of potent purine-d ...... trypanosomal protease TbcatB.
@en
P2093
Aaron Kosinski
Anang A Shelat
Conor R Caffrey
Doron Greenbaum
Jeremy P Mallari
Michael Harbut
Michele Connelly
R Kiplin Guy
Terri Obrien
P304
P356
10.1021/JM070760L
P407
P577
2008-01-04T00:00:00Z