Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3. - Wikidata - awgldk - TriplyDB

Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3.

Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3.

http://www.wikidata.org/entity/Q40030085

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PDZ domains and their binding partners: structure, specificity, and modification Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites Melanoma Brain Metastasis: Mechanisms, Models, and Medicine Detailed regulatory mechanism of the interaction between ZO-1 PDZ2 and connexin43 revealed by MD simulations Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair.Mechanisms of gap junction traffic in health and disease A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia.Identification of CaMKII phosphorylation sites in Connexin43 by high-resolution mass spectrometry.PLEKHA5 as a Biomarker and Potential Mediator of Melanoma Brain Metastasis.Prognostic impact of reduced connexin43 expression and gap junction coupling of neoplastic stromal cells in giant cell tumor of bone Activation of Akt, not connexin 43 protein ubiquitination, regulates gap junction stability Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition.Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells.Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision.Molecular mechanisms regulating formation, trafficking and processing of annular gap junctions.Ubiquitination, intracellular trafficking, and degradation of connexins Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1.Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells.Coregulation of multiple signaling mechanisms in pp60v-Src-induced closure of Cx43 gap junction channels.Phosphorylation of serine residues in the C-terminal cytoplasmic tail of connexin43 regulates proliferation of ovarian granulosa cells Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism.Regulation of Connexin43 Function and Expression by Tyrosine Kinase 2.Proteins and mechanisms regulating gap-junction assembly, internalization, and degradation.Managing the complexity of communication: regulation of gap junctions by post-translational modification.Discovering the molecular components of intercellular junctions--a historical view.Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size.Specific Cx43 phosphorylation events regulate gap junction turnover in vivo Membrane proteins as 14-3-3 clients in functional regulation and intracellular transport.Plasticity of PDZ domains in ligand recognition and signaling.Degradation of connexins through the proteasomal, endolysosomal and phagolysosomal pathways.Regulation of connexin- and pannexin-based channels by post-translational modifications.Melanoma central nervous system metastases: current approaches, challenges, and opportunities.Biphasic Effect of Basic Fibroblast Growth Factor on Anterior Pituitary Folliculostellate TtT/GF Cell Coupling, and Connexin 43 Expression and Phosphorylation.EGF-Induced Connexin43 Negatively Regulates Cell Proliferation in Human Ovarian Cancer.Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics.Epidermal growth factor regulates connexin 43 in the human epididymis: role of gap junctions in azoospermia.Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage.Progesterone Via its Type-A Receptor Promotes Myometrial Gap Junction Coupling.

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P2860

Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3.

http://www.wikidata.org/entity/Q40030085

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3.

@en

type

label

Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3.

@en

prefLabel

Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3.

@en

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15419060701755958

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Cell Communication & Adhesion

P1476

Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3.

@en

P2093

Alan F Lau

http://www.w3.org/2001/XMLSchema#string

Bonnie J Warn-Cramer

http://www.w3.org/2001/XMLSchema#string

Chengshi Jin

http://www.w3.org/2001/XMLSchema#string

Christopher J Wallick

http://www.w3.org/2001/XMLSchema#string

Darren J Park

http://www.w3.org/2001/XMLSchema#string

Kendra D Martyn

http://www.w3.org/2001/XMLSchema#string

P2860

Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation

Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells

CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

The effects of connexin phosphorylation on gap junctional communication

Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)

Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy

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211-226

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10.1080/15419060701755958

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5

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14

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5686721

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18163231

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phosphorylation

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2673107

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