B-Raf(V600E) signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells.
about
Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomasHigh-content, high-throughput analysis of cell cycle perturbations induced by the HSP90 inhibitor XL888Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cellsPin1 promotes transforming growth factor-beta-induced migration and invasion.The MPS1 family of protein kinases.Degradation of the human mitotic checkpoint kinase Mps1 is cell cycle-regulated by APC-cCdc20 and APC-cCdh1 ubiquitin ligases.Antizyme restrains centrosome amplification by regulating the accumulation of Mps1 at centrosomesDifferential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signalingPrioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM).Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1.A MEK-independent role for CRAF in mitosis and tumor progression.The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models.Aurora B is regulated by the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway and is a valuable potential target in melanoma cells.Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age.A novel role for Cdk1/cyclin B in regulating B-raf activation at mitosisRegulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylationRole of prolonged mitotic checkpoint activation in the formation and treatment of cancer.TTK is a favorable prognostic biomarker for triple-negative breast cancer survival.Targeting aneuploid cancer cells.Mechanisms of aneuploidy induction by RAS and RAF oncogenesDownregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma.P16 overexpression in BRAF-mutated gastrointestinal stromal tumors.Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma.B-Raf associates with and activates the NHE1 isoform of the Na+/H+ exchanger.A look into centrosome abnormalities in colon cancer cells, how they arise and how they might be targeted therapeutically.High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint.
P2860
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P2860
B-Raf(V600E) signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
B-Raf(V600E) signaling deregul ...... Mps1 levels in melanoma cells.
@en
type
label
B-Raf(V600E) signaling deregul ...... Mps1 levels in melanoma cells.
@en
prefLabel
B-Raf(V600E) signaling deregul ...... Mps1 levels in melanoma cells.
@en
P2860
P356
P1433
P1476
B-Raf(V600E) signaling deregul ...... Mps1 levels in melanoma cells.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210972
P407
P577
2007-12-10T00:00:00Z
P5875
P6179
1030898966