The leukemogenic CALM/AF10 fusion protein alters the subcellular localization of the lymphoid regulator Ikaros.
about
Role of Ikaros in T-cell acute lymphoblastic leukemiaASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category.AF10 plays a key role in the survival of uncommitted hematopoietic cells.Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemiaRegulator of myeloid differentiation and function: The secret life of Ikaros.FHL2 interacts with CALM and is highly expressed in acute erythroid leukemia.A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest.CATS (FAM64A) abnormal expression reduces clonogenicity of hematopoietic cells.Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development.Ikaros and leukaemia.The upstreams and downstreams of H3K79 methylation by DOT1L.Identification and characterization of OSTL (RNF217) encoding a RING-IBR-RING protein adjacent to a translocation breakpoint involving ETV6 in childhood ALL.The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice.The CALM and CALM/AF10 interactor CATS is a marker for proliferation.Tumor suppression in T cell leukemia--the role of Ikaros.Up a lymphoid blind alley: Does CALM/AF10 disturb Ikaros during leukemogenesis?Identifying the immunodeficiency gateway proteins in humans and their involvement in microRNA regulation.The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12.
P2860
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P2860
The leukemogenic CALM/AF10 fusion protein alters the subcellular localization of the lymphoid regulator Ikaros.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The leukemogenic CALM/AF10 fus ...... the lymphoid regulator Ikaros.
@en
type
label
The leukemogenic CALM/AF10 fus ...... the lymphoid regulator Ikaros.
@en
prefLabel
The leukemogenic CALM/AF10 fus ...... the lymphoid regulator Ikaros.
@en
P2093
P2860
P356
P1433
P1476
The leukemogenic CALM/AF10 fus ...... the lymphoid regulator Ikaros.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210945
P407
P577
2007-11-26T00:00:00Z
P5875
P6179
1006419184