about
High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains.POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer.Hoxa6 potentiates short-term hemopoietic cell proliferation and extended self-renewal.The pathophysiology of HOX genes and their role in cancer.Grappling with the HOX network in hematopoiesis and leukemia.Low-dose salinomycin induces anti-leukemic responses in AML and MLL.Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing.Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia.Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis.Protein arginine-methyltransferase-dependent oncogenesis.Targeted deletion of the Hoxa cluster affects B lymphopoiesis through depletion of early lymphoid progenitors.Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells.Global down-regulation of HOX gene expression in PML-RARalpha + acute promyelocytic leukemia identified by small-array real-time PCR.Signaling by the Mpl receptor involves IKK and NF-kappaB.Decitabine-Vorinostat combination treatment in acute myeloid leukemia activates pathways with potential for novel triple therapy.Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells.Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy.c-Met inhibition in a HOXA9/Meis1 model of CN-AML.HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy.Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia.Hoxa9 collaborates with E2A-PBX1 in mouse B cell leukemia in association with Flt3 activation and decrease of B cell gene expression.Prolonged molecular remission in PML-RARalpha-positive acute promyelocytic leukemia treated with minimal chemotherapy followed by maintenance including the histone deacetylase inhibitor sodium valproate.Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells.Thrombopoietin, flt3-ligand and c-kit-ligand modulate HOX gene expression in expanding cord blood CD133 cells.Correlation of TACC3, FGFR3, MMSET and p21 expression with the t(4;14)(p16.3;q32) in multiple myeloma.Repression of A TAF(II)32 isoform as part of a program of genes regulated during mpl ligand-induced megakaryocyte differentiation.Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells.Complete array of HOX gene expression by RQ-PCR.Quantification of Hox and surfactant protein-B transcription during murine lung development.Deregulated expression of c-myc in megakaryocytes of transgenic mice increases megakaryopoiesis and decreases polyploidization.A New Transgenic Mouse Model for the Study of Cell Cycle Control in MegakaryocytesEffects of nitric oxide inhibition on systemic and renal hemodynamics in the hemorrhaged ratEndothelin receptor A blockade alters hemodynamic response to nitric oxide inhibition in ratsStroma-free hemoglobin increases blood pressure and GFR in the hypotensive rat: role of nitric oxideOverexpression of cyclin D1 moderately increases ploidy in megakaryocytesMolecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activationHoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cellsHOX genes in normal, engineered and malignant hematopoiesisThe histone deacetylase inhibitor Romidepsin induces as a cascade of differential gene expression and altered histone H3K9 marks in myeloid leukaemia cells
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Alex Thompson
@ast
Alex Thompson
@en
Alex Thompson
@es
Alex Thompson
@nl
type
label
Alex Thompson
@ast
Alex Thompson
@en
Alex Thompson
@es
Alex Thompson
@nl
prefLabel
Alex Thompson
@ast
Alex Thompson
@en
Alex Thompson
@es
Alex Thompson
@nl
P106
P21
P31
P496
0000-0002-9315-5321