Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells.
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HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cellsA myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA clusterMisguided transcriptional elongation causes mixed lineage leukemiaGenome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemiaHoxA10 regulates transcription of the gene encoding transforming growth factor beta2 (TGFbeta2) in myeloid cells.Regulation of CDX4 gene transcription by HoxA9, HoxA10, the Mll-Ell oncogene and Shp2 during leukemogenesisDown-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferationUp-regulation of homeodomain genes, DLX1 and DLX2, by FLT3 signalingMLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.HoxA10 protein regulates transcription of gene encoding fibroblast growth factor 2 (FGF2) in myeloid cells.Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemiaHOX genes: seductive science, mysterious mechanisms.β-Catenin activates the HOXA10 and CDX4 genes in myeloid progenitor cells.Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2aMLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.First among equals: the cancer cell hierarchy.Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.The molecular biology of mixed lineage leukemia.Mixed lineage leukemia: roles in human malignancies and potential therapy.The role of Hox proteins in leukemogenesis: insights into key regulatory events in hematopoiesis.Recent advances in acute myeloid leukemia stem cell biologyThe AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis.Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors.HOX proteins and leukemia.Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid LeukemiaH2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemiaTGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia.Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation.MLL-AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny.Targeting acute myeloid leukemia by drug-induced c-MYB degradation.Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model.Clonal expansion of non-leukemic cells expressing two novel MLL-ELL variants differing in transforming activity.Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4·MLL fusion allele
P2860
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P2860
Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Continuous MLL-ENL expression ...... ematopoietic progenitor cells.
@en
type
label
Continuous MLL-ENL expression ...... ematopoietic progenitor cells.
@en
prefLabel
Continuous MLL-ENL expression ...... ematopoietic progenitor cells.
@en
P2093
P1433
P1476
Continuous MLL-ENL expression ...... ematopoietic progenitor cells.
@en
P2093
Dale A Moulding
David G Grier
Dimitris Kioussis
Glenda J McGonigle
Hugh J M Brady
Inusha De Silva
Michelle Morrow
Owen Williams
Sarah J Horton
Terence R J Lappin
P304
P356
10.1158/0008-5472.CAN-05-1691
P407
P577
2005-10-01T00:00:00Z