about
Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometryp53-Dependent anticancer effects of leptomycin B on lung adenocarcinomaThe mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.p53 Amino-terminus region (1-125) stabilizes and restores heat denatured p53 wild phenotype.14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer.Deconstructing nucleotide binding activity of the Mdm2 RING domain.Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells.MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.Inhibition of p53 DNA binding function by the MDM2 protein acidic domain.Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival.p53 and MDM2 are involved in the regulation of osteocalcin gene expression.Splicing up mdm2 for cancer proteome diversity.Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to folGossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer.FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2.Transient protein-protein interactions.Mdm2 and MdmX as Regulators of Gene ExpressioncncRNAs: Bi-functional RNAs with protein coding and non-coding functionsMDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanismA function for the RING finger domain in the allosteric control of MDM2 conformation and activity.Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops.Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif.ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway.Inhibition of MDM2 by a rhein-derived compound AQ-101 suppresses cancer development in SCID mice.Different apoptotic responses of RA synoviocytes depending on different genotypes of the mdm2 SNP T309G.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
MDM2 chaperones the p53 tumor suppressor.
@en
type
label
MDM2 chaperones the p53 tumor suppressor.
@en
prefLabel
MDM2 chaperones the p53 tumor suppressor.
@en
P2093
P2860
P356
P1476
MDM2 chaperones the p53 tumor suppressor.
@en
P2093
Alicja Zylicz
Maura Wallace
P2860
P304
32603-32612
P356
10.1074/JBC.M702767200
P407
P577
2007-09-11T00:00:00Z