Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif.
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Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometryIn vitro selection of mutant HDM2 resistant to Nutlin inhibitionSimulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamicsEfficacy and Mechanism of Action of Low Dose Emetine against Human CytomegalovirusModulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53Homozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death.Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells.Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation: the functional role of Ser17 phosphorylation in MDM2 reexamined.Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development.MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond.Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein-protein interactions by the MDM2 ligand nutlin-3.CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability.The use of ion mobility mass spectrometry to probe modulation of the structure of p53 and of MDM2 by small molecule inhibitorsConcepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops.p53 promotes its own polyubiquitination by enhancing the HDM2 and HDMX interaction.
P2860
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P2860
Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Regulation of the E3 ubiquitin ...... rminal pseudo-substrate motif.
@en
Regulation of the E3 ubiquitin ...... rminal pseudo-substrate motif.
@nl
type
label
Regulation of the E3 ubiquitin ...... rminal pseudo-substrate motif.
@en
Regulation of the E3 ubiquitin ...... rminal pseudo-substrate motif.
@nl
prefLabel
Regulation of the E3 ubiquitin ...... rminal pseudo-substrate motif.
@en
Regulation of the E3 ubiquitin ...... rminal pseudo-substrate motif.
@nl
P2093
P2860
P1476
Regulation of the E3 ubiquitin ...... rminal pseudo-substrate motif.
@en
P2093
Erin G Worrall
Kathryn L Ball
Liam Worrall
Ted R Hupp
P2860
P2888
P304
P356
10.1007/S12154-009-0019-5
P577
2009-05-16T00:00:00Z