Further evidence for two functional forms of prothrombinase each specific for either of the two prothrombin activation cleavages.
about
Na+ binding to meizothrombin desF1The linker connecting the two kringles plays a key role in prothrombin activationContribution of Amino Acid Region 659−663 of Factor Va Heavy Chain to the Activity of Factor Xa within Prothrombinase,Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrateA revisit to the one form kinetic model of prothrombinaseImproved hemostasis in hemophilia mice by means of an engineered factor Va mutantEvidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa.Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity.Meizothrombin is an unexpectedly zymogen-like variant of thrombin.Prothrombin activation in blood coagulation: the erythrocyte contribution to thrombin generation.Prothrombin activation by platelet-associated prothrombinase proceeds through the prethrombin-2 pathway via a concerted mechanism.Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase.How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of ProthrombinThe transition of prothrombin to thrombin.Membrane binding by prothrombin mediates its constrained presentation to prothrombinase for cleavageRole of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinase.Differences in prethrombin-1 activation with human or bovine factor Va can be attributed to the heavy chain.Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C.Structure of Coagulation Factor II: Molecular Mechanism of Thrombin Generation and Development of Next-Generation Anticoagulants
P2860
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P2860
Further evidence for two functional forms of prothrombinase each specific for either of the two prothrombin activation cleavages.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Further evidence for two funct ...... thrombin activation cleavages.
@en
type
label
Further evidence for two funct ...... thrombin activation cleavages.
@en
prefLabel
Further evidence for two funct ...... thrombin activation cleavages.
@en
P2860
P356
P1476
Further evidence for two funct ...... thrombin activation cleavages.
@en
P2093
Michael E Nesheim
Paul Y Kim
P2860
P304
32568-32581
P356
10.1074/JBC.M701781200
P407
P577
2007-08-28T00:00:00Z