Dark rearing rescues P23H rhodopsin-induced retinal degeneration in a transgenic Xenopus laevis model of retinitis pigmentosa: a chromophore-dependent mechanism characterized by production of N-terminally truncated mutant rhodopsin.
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Xenopus research: metamorphosed by genetics and genomicsAn inducible expression system to measure rhodopsin transport in transgenic Xenopus rod outer segmentsMeckelin 3 is necessary for photoreceptor outer segment development in rat Meckel syndromeExpression of two endoplasmic reticulum stress markers, GRP78 and GADD153, in rat retinal detachment model and its implication.Mutant ELOVL4 that causes autosomal dominant stargardt-3 macular dystrophy is misrouted to rod outer segment disksModulation of cellular signaling pathways in P23H rhodopsin photoreceptors.Chaperoning G protein-coupled receptors: from cell biology to therapeuticsRescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation.Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration.Xenopus laevis P23H rhodopsin transgene causes rod photoreceptor degeneration that is more severe in the ventral retina and is modulated by light.Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosaProbing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations.Autofluorescence imaging with near-infrared excitation:normalization by reflectance to reduce signal from choroidal fluorophores.A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.Genetically modified species in research: Opportunities and challenges for the histology core laboratory.Light Induces Ultrastructural Changes in Rod Outer and Inner Segments, Including Autophagy, in a Transgenic Xenopus laevis P23H Rhodopsin Model of Retinitis Pigmentosa.Autophagy in light-induced retinal damage.NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degenerationDysmorphic photoreceptors in a P23H mutant rhodopsin model of retinitis pigmentosa are metabolically active and capable of regenerating to reverse retinal degeneration.Signals governing the trafficking and mistrafficking of a ciliary GPCR, rhodopsin.Assessment of visual function and retinal structure following acute light exposure in the light sensitive T4R rhodopsin mutant dogRetinitis pigmentosa mutants provide insight into the role of the N-terminal cap in rhodopsin folding, structure, and function.A homozygous p.Glu150Lys mutation in the opsin gene of two Pakistani families with autosomal recessive retinitis pigmentosa.P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis.Gene therapy in animal models of autosomal dominant retinitis pigmentosaMolecular basis for photoreceptor outer segment architecture.Structural and molecular bases of rod photoreceptor morphogenesis and disease.Retinal Degeneration and Regeneration-Lessons From Fishes and Amphibians.The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control.A Pro23His mutation alters prenatal rod photoreceptor morphology in a transgenic swine model of retinitis pigmentosa.Examining rhodopsin retention in endoplasmic reticulum and intracellular localization in vitro and in vivo by using truncated rhodopsin fragments.Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa.Modeling Dominant and Recessive Forms of Retinitis Pigmentosa by Editing Three Rhodopsin-Encoding Genes in Xenopus Laevis Using Crispr/Cas9.Identification of three prominin homologs and characterization of their messenger RNA expression in Xenopus laevis tissues.The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy.Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision.Targeted disruption of the endogenous zebrafish locus as models of rapid rod photoreceptor degeneration
P2860
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P2860
Dark rearing rescues P23H rhodopsin-induced retinal degeneration in a transgenic Xenopus laevis model of retinitis pigmentosa: a chromophore-dependent mechanism characterized by production of N-terminally truncated mutant rhodopsin.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Dark rearing rescues P23H rhod ...... ly truncated mutant rhodopsin.
@en
type
label
Dark rearing rescues P23H rhod ...... ly truncated mutant rhodopsin.
@en
prefLabel
Dark rearing rescues P23H rhod ...... ly truncated mutant rhodopsin.
@en
P1476
Dark rearing rescues P23H rhod ...... lly truncated mutant rhodopsin
@en
P2093
Beatrice M Tam
P304
P356
10.1523/JNEUROSCI.2245-07.2007
P407
P577
2007-08-01T00:00:00Z