Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
about
The hyperimmunoglobulin E syndrome--clinical manifestation diversity in primary immune deficiencyThe genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control studyHost-microbe interactions have shaped the genetic architecture of inflammatory bowel diseaseJanus kinases in immune cell signalingAutosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairmentT helper 17 cell heterogeneity and pathogenicity in autoimmune diseaseCombined immunodeficiency associated with DOCK8 mutationsGenetic interstitial lung diseaseGenomic views of STAT function in CD4+ T helper cell differentiationPrimary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification CommitteeA homozygous CARD9 mutation in a family with susceptibility to fungal infectionsStable long-term cultures of self-renewing B cells and their applicationsMedical case reports in the age of genomic medicineIL-17-Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicansEosinophilia Associated with Disorders of Immune Deficiency or Immune DysregulationSTAT3 and the Hyper-IgE syndrome: Clinical presentation, genetic origin, pathogenesis, novel findings and remaining uncertaintiesT-regulatory cells in primary immune deficienciesPouring fuel on the fire: Th17 cells, the environment, and autoimmunityHyper-IgE syndrome updateNewly recognized Mendelian disorders with rheumatic manifestationsMucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapyAn update on the hyper-IgE syndromesMendelian genetics of human susceptibility to fungal infectionThe IL-23-IL-17 immune axis: from mechanisms to therapeutic testingCancers Related to Immunodeficiencies: Update and PerspectivesFlow Cytometry, a Versatile Tool for Diagnosis and Monitoring of Primary ImmunodeficienciesPrimary immunodeficiency update: Part I. Syndromes associated with eczematous dermatitisEarly-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutationsHuman TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeClinical manifestations, etiology, and pathogenesis of the hyper-IgE syndromesSTATs in cancer inflammation and immunity: a leading role for STAT3Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndromeDifferentiation of effector CD4 T cell populations (*)STAT3 single-nucleotide polymorphisms and STAT3 mutations associated with hyper-IgE syndrome are not responsible for increased serum IgE serum levels in asthma families.Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.Fraternal twins with job's syndrome and immune complex nephritisGenome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I
P2860
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P2860
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
@en
type
label
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
@en
prefLabel
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
@en
P2093
P356
P1433
P1476
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
@en
P2093
Ayse Metin
Hidetoshi Takada
Ikuya Tsuge
Masako Saito
Nobuaki Kawamura
Oliver Stojkovic
Shigeru Tsuchiya
Srdjan Pasic
Tadashi Ariga
Toshiro Hara
P2888
P304
P356
10.1038/NATURE06096
P407
P577
2007-08-05T00:00:00Z
P5875
P6179
1036072632