Methylation-acetylation interplay activates p53 in response to DNA damage. - Wikidata - awgldk - TriplyDB

Methylation-acetylation interplay activates p53 in response to DNA damage.

Methylation-acetylation interplay activates p53 in response to DNA damage.

http://www.wikidata.org/entity/Q40103473

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Methylation of the retinoblastoma tumor suppressor by SMYD2 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail The functional diversity of protein lysine methylation An unexpected journey: lysine methylation across the proteome Transcriptional regulation by the Set7 lysine methyltransferase The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression Histone methylation modifiers in cellular signaling pathways p53 Acetylation: Regulation and Consequences Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization Epigenetic histone methylation modulates fibrotic gene expression Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes The proteomic to biology inference, a frequently overlooked concern in the interpretation of proteomic data: a plea for functional validation.Protein post-translational modifications: In silico prediction tools and molecular modeling.Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53 Dynamics of posttranslational modifications of p53.Posttranslational modification of p53: cooperative integrators of function Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).Substrate and product specificities of SET domain methyltransferases Role of lysine methylation of NF-κB in differential gene regulation Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).An acetyl-methyl switch drives a conformational change in p53.Impact of the adenoviral E4 Orf3 protein on the activity and posttranslational modification of p53.Systematic characterization and prediction of post-translational modification cross-talk.Regulation of p53 function by lysine methylation.SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21 The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription.Surf the post-translational modification network of p53 regulation A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines Molecular dynamic simulation insights into the normal state and restoration of p53 function.Methylation by Set9 modulates FoxO3 stability and transcriptional activity.SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence.Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression Unlocking repression of the human luteinizing hormone receptor gene by trichostatin A-induced cell-specific phosphatase release.Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase.

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Methylation-acetylation interplay activates p53 in response to DNA damage.

http://www.wikidata.org/entity/Q40103473

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Methylation-acetylation interplay activates p53 in response to DNA damage.

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Methylation-acetylation interplay activates p53 in response to DNA damage.

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Molecular and Cellular Biology

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Methylation-acetylation interplay activates p53 in response to DNA damage.

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Alexey Ivanov

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Danny Reinberg

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Enrique M Herrera-Medina

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Farid Gizatullin

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Frank Rauscher

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Gleb S Ivanov

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Julia Kurash

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Nickolai A Barlev

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Sergey Chuikov

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Tatyana Ivanova

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P2860

p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity

Regulation of p53 activity through lysine methylation

A model for p53-induced apoptosis

Repression of p53 activity by Smyd2-mediated methylation

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

Gene-specific modulation of TAF10 function by SET9-mediated methylation

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.

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