Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance.
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CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifenEndoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogensTamoxifen but not 4-hydroxytamoxifen initiates apoptosis in p53(-) normal human mammary epithelial cells by inducing mitochondrial depolarization.Postnatal lineage mapping of follicular melanocytes with the Tyr::CreER(T) (2) transgeneCombination therapy with anti-DR5 antibody and tamoxifen for triple negative breast cancer.Clinical Relevance of CYP2D6 Genetics for Tamoxifen Response in Breast Cancer.Selective estrogen receptor modulators: tissue specificity and clinical utility.Tamoxifen and raloxifene modulate gap junction coupling during early phases of retinoic acid-dependent neuronal differentiation of NTera2/D1 cells.Tamoxifen metabolite concentrations, CYP2D6 genotype, and breast cancer outcomes.Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifenMetabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversyClinical epidemiology and pharmacology of CYP2D6 inhibition related to breast cancer outcomes.An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.Pharmacokinetics of endoxifen and tamoxifen in female mice: implications for comparative in vivo activity studies.Study of tamoxifen urinary metabolites in rat by ultra-high-performance liquid chromatography time-of-flight mass spectrometry.Peroxidase-mediated dealkylation of tamoxifen, detected by electrospray ionization-mass spectrometry, and activation to form DNA adducts.Genotoxic mechanism of tamoxifen in developing endometrial cancer.CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial.Boronic prodrug of endoxifen as an effective hormone therapy for breast cancer.Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiolBioactivation of the cancer chemopreventive agent tamoxifen to quinone methides by cytochrome P4502B6 and identification of the modified residue on the apoproteinThe role of genetic variability in drug metabolism pathways in breast cancer prognosis.Functional polymorphisms in xenobiotic metabolizing enzymes and their impact on the therapy of breast cancer.Bioactivation of Selective Estrogen Receptor Modulators (SERMs)Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug responseBoron-Based 4-Hydroxytamoxifen Bioisosteres for Treatment of de Novo Tamoxifen Resistant Breast Cancer.Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment.Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer.Cytochrome P-450 2D6 (CYP2D6) Genotype and Breast Cancer Recurrence in Tamoxifen-Treated Patients: Evaluating the Importance of Loss of Heterozygosity.Germline pharmacogenetics of tamoxifen response: have we learned enough?Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial.Biomonitoring of urinary tamoxifen and its metabolites from breast cancer patients using nonaqueous capillary electrophoresis with electrospray mass spectrometry.Chemoprevention with antiestrogens: the beginning of the end for breast cancer. Daniel G. Miller Lecture.Combining genetic variations in CYP2C9 and VKORC1 with clinical factors for warfarin dosing determination improved clinical effectiveness.Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer.Characterization of the biotransformation pathways of clomiphene, tamoxifen and toremifene as assessed by LC-MS/(MS) following in vitro and excretion studies.Selective Estrogen Receptor Modulators
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P2860
Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance.
description
1982 nî lūn-bûn
@nan
1982年の論文
@ja
1982年学术文章
@wuu
1982年学术文章
@zh-cn
1982年学术文章
@zh-hans
1982年学术文章
@zh-my
1982年学术文章
@zh-sg
1982年學術文章
@yue
1982年學術文章
@zh
1982年學術文章
@zh-hant
name
Metabolites of tamoxifen in an ...... harmacology, and significance.
@en
type
label
Metabolites of tamoxifen in an ...... harmacology, and significance.
@en
prefLabel
Metabolites of tamoxifen in an ...... harmacology, and significance.
@en
P2860
P356
P1476
Metabolites of tamoxifen in an ...... harmacology, and significance.
@en
P2093
V C Jordan
P2860
P2888
P304
P356
10.1007/BF01806449
P407
P577
1982-01-01T00:00:00Z
P6179
1044709335