Replication of an acutely lethal simian immunodeficiency virus activates and induces proliferation of lymphocytes.
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Regions of human immunodeficiency virus type 1 nef required for function in vivoNef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo.Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing disease.Simian-human immunodeficiency virus (SHIV) containing the nef/long terminal repeat region of the highly virulent SIVsmmPBj14 causes PBj-like activation of cultured resting peripheral blood mononuclear cells, but the chimera showed No increase in virPostinoculation PMPA treatment, but not preinoculation immunomodulatory therapy, protects against development of acute disease induced by the unique simian immunodeficiency virus SIVsmmPBj.Biologic studies of chimeras of highly and moderately virulent molecular clones of simian immunodeficiency virus SIVsmPBj suggest a critical role for envelope in acute AIDS virus pathogenesis.Relative replication capacity of phenotypic SIV variants during primary infections differs with route of inoculation.The U3 promoter region of the acutely lethal simian immunodeficiency virus clone smmPBj1.9 confers related biological activity on the apathogenic clone agm3mc.The ITAM in Nef influences acute pathogenesis of AIDS-inducing simian immunodeficiency viruses SIVsm and SIVagm without altering kinetics or extent of viremiaAn acutely lethal simian immunodeficiency virus stimulates expansion of V beta 7- and V beta 14-expressing T lymphocytes.Molecular and biological analyses of quasispecies during evolution of a virulent simian immunodeficiency virus, SIVsmmPBj14.Requirements for lymphocyte activation by unusual strains of simian immunodeficiency virus.Selective anergy of V beta 8+ T cells in human immunodeficiency virus-infected individuals.Immune activation and viral burden in acute disease induced by simian immunodeficiency virus SIVsmmPBj14: correlation between in vitro and in vivo events.Multiple viral determinants contribute to pathogenicity of the acutely lethal simian immunodeficiency virus SIVsmmPBj variant.Early events in immune evasion by the lentivirus maedi-visna occurring within infected lymphoid tissue.Ovine lentivirus is macrophagetropic and does not replicate productively in T lymphocytes.Characterization of the Jembrana disease virus tat gene and the cis- and trans-regulatory elements in its long terminal repeats.A lymph node-derived cytopathic simian immunodeficiency virus Mne variant replicates in nonstimulated peripheral blood mononuclear cells.The U3 promoter and the nef gene of simian immunodeficiency virus (SIV) smmPBj1.9 do not confer acute pathogenicity upon SIVagm.Molecular cloning and characterization of viruses isolated from chimpanzees with pathogenic human immunodeficiency virus type 1 infections.Costimulatory pathways in lymphocyte proliferation induced by the simian immunodeficiency virus SIVsmmPBj14.Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus.Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14.Interaction between Nef and INI1/SMARCB1 augments replicability of HIV-1 in resting human peripheral blood mononuclear cells.The SCHOOL of nature: IV. Learning from viruses.Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease.
P2860
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P2860
Replication of an acutely lethal simian immunodeficiency virus activates and induces proliferation of lymphocytes.
description
1991 nî lūn-bûn
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1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
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1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
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1991年學術文章
@zh
1991年學術文章
@zh-hant
name
Replication of an acutely leth ...... proliferation of lymphocytes.
@en
type
label
Replication of an acutely leth ...... proliferation of lymphocytes.
@en
prefLabel
Replication of an acutely leth ...... proliferation of lymphocytes.
@en
P2860
P1433
P1476
Replication of an acutely leth ...... s proliferation of lymphocytes
@en
P2093
P2860
P304
P407
P577
1991-09-01T00:00:00Z