Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms.
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REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cellsExtreme-longevity mutations orchestrate silencing of multiple signaling pathwaysp38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational AnalysesCrystal structure of the p38α MAP kinase in complex with a docking peptide from TAB1Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbationsDevelopment of sulfonamide AKT PH domain inhibitors.Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine.Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia.AF1q Mediates Tumor Progression in Colorectal Cancer by Regulating AKT Signaling.Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Activation of Akt by the bacterial inositol phosphatase, SopB, is wortmannin insensitive.The p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cellsPhosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells.Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.The differential regulation of p38α by the neuronal kinase interaction motif protein tyrosine phosphatases, a detailed molecular studyBrain cancer stem cells display preferential sensitivity to Akt inhibition.Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells.Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia.Phosphatidylinositol 3-kinases inhibitor LY294002 potentiates the cytotoxic effects of doxorubicin, vincristine, and etoposide in a panel of cancer cell lines.Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants.DEF pocket in p38α facilitates substrate selectivity and mediates autophosphorylation.Conformational bias imposed by source microseeds results in structural ambiguity.d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway.
P2860
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P2860
Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Phosphatidylinositol ether lip ...... ent and -dependent mechanisms.
@en
type
label
Phosphatidylinositol ether lip ...... ent and -dependent mechanisms.
@en
prefLabel
Phosphatidylinositol ether lip ...... ent and -dependent mechanisms.
@en
P2093
P2860
P356
P1476
Phosphatidylinositol ether lip ...... dent and -dependent mechanisms
@en
P2093
Alan P Kozikowski
Chunyu Zhang
Jiahuai Han
Joell J Gills
Melinda Hollingshead
Pavel A Petukhov
Phillip A Dennis
Regan M Memmott
S Sianna Castillo
P2860
P304
27020-27029
P356
10.1074/JBC.M701108200
P407
P577
2007-07-13T00:00:00Z