Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1. - Wikidata - awgldk - TriplyDB

Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

http://www.wikidata.org/entity/Q40109092

about

γ-Secretase inhibitors and modulators.Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide Peptidase Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans.Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin.Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.Steroids as γ-secretase modulators.Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.Development and mechanism of γ-secretase modulators for Alzheimer's disease.Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012.Recent advances in target characterization and identification by photoaffinity probes.Recent developments and applications of clickable photoprobes in medicinal chemistry and chemical biology.Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase.Target of γ-secretase modulators, presenilin marks the spot.Development of CBAP-BPyne, a probe for γ-secretase and presenilinase.Development of clickable active site-directed photoaffinity probes for γ-secretase.BMS-708,163 targets presenilin and lacks notch-sparing activity.Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein.Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.Structural and Chemical Biology of Presenilin Complexes.An efficient protocol towards site-specifically clickable nanobodies in high yield: cytoplasmic expression in Escherichia coli combined with intein-mediated protein ligation.

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P2860

Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

http://www.wikidata.org/entity/Q40109092

description

2011 nî lūn-bûn

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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2011年學術文章

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2011年學術文章

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name

Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

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type

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Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

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Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

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ACS Chemical Neuroscience

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Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

@en

P2093

Benjamin A Fish

http://www.w3.org/2001/XMLSchema#string

Christina J Crump

http://www.w3.org/2001/XMLSchema#string

Cory Stiff

http://www.w3.org/2001/XMLSchema#string

De-Ming Chau

http://www.w3.org/2001/XMLSchema#string

Douglas S Johnson

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Kelly R Bales

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Kwangwook Ahn

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Natalya Gertsik

http://www.w3.org/2001/XMLSchema#string

Nikolay Pozdnyakov

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Suita V Castro

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P2860

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

Identification of signal peptide peptidase, a presenilin-type aspartic protease

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

Alzheimer's disease: the amyloid cascade hypothesis

The canonical Notch signaling pathway: unfolding the activation mechanism.

Click chemistry and bioorthogonal reactions: unprecedented selectivity in the labeling of biological molecules.

Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease.

Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.

Beta-amyloid precursor protein mutants respond to gamma-secretase modulators

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705-710

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scholarly article

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10.1021/CN200098P

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12

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2

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2011-12-01T00:00:00Z

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221732906

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22229075

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