Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.
about
Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasetsAn siRNA screen identifies RSK1 as a key modulator of lung cancer metastasisNeutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignanciesInvolvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formationSphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ERIntracellular trafficking of ceramide by ceramide transfer proteinThe sphingolipid salvage pathway in ceramide metabolism and signalingQuantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fateRoles of bioactive sphingolipids in cancer biology and therapeuticsTrafficking and Functions of Bioactive Sphingolipids: Lessons from Cells and Model MembranesUsing large-scale genomics data to identify driver mutations in lung cancer: methods and challengesEvolving concepts in cancer therapy through targeting sphingolipid metabolismPolo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancerSynthetic lethality in lung cancer and translation to clinical therapiesRNAi screening with shRNAs against histone methylation-related genes reveals determinants of sorafenib sensitivity in hepatocellular carcinoma cellsA new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosisAn intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitorAnalysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinomeMechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signallingPraziquantel synergistically enhances paclitaxel efficacy to inhibit cancer cell growthMitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant miceSpindle poisons and cell fate: a tale of two pathways.Human cancer cells commonly acquire DNA damage during mitotic arrest.High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisonsRegulation of mitosis and taxane response by Daxx and Rassf1.The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality controlAnalysis of high-throughput RNAi screening data in identifying genes mediating sensitivity to chemotherapeutic drugs: statistical approaches and perspectivesIncreasing the robustness and validity of RNAi screens.Single cell cytometry of protein function in RNAi treated cells and in native populationsRNA interference screening demystified.Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.Reduced NF1 expression confers resistance to EGFR inhibition in lung cancerHigh-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instabilityPhosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells.Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.Using functional genetics to understand breast cancer biologyComprehensive mapping of the human kinome to epidermal growth factor receptor signalingAkt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer.Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.
P2860
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P2860
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Regulators of mitotic arrest a ...... other chemotherapeutic drugs.
@en
type
label
Regulators of mitotic arrest a ...... other chemotherapeutic drugs.
@en
prefLabel
Regulators of mitotic arrest a ...... other chemotherapeutic drugs.
@en
P2093
P50
P1433
P1476
Regulators of mitotic arrest a ...... d other chemotherapeutic drugs
@en
P2093
Ahmed A Ahmed
Barbara Nicke
Jenny Chang
Jillian Temple
Michela Marani
Olivier Pardo
Patricia H Warne
P304
P356
10.1016/J.CCR.2007.04.011
P577
2007-06-01T00:00:00Z