Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines.
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Pharmacogenetics predictive of response and toxicity in acute lymphoblastic leukemia therapyThe glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells.Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines.Targeted metabolomic analysis of amino acid response to L-asparaginase in adherent cellsPharmacokinetic modeling of an induction regimen for in vivo combined testing of novel drugs against pediatric acute lymphoblastic leukemia xenografts.Asparagine synthetase: regulation by cell stress and involvement in tumor biologyA genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity.ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia.The transcription factor network associated with the amino acid response in mammalian cells.The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.Cancer cell metabolism: one hallmark, many faces.Genome-wide loss-of-function genetic screening identifies opioid receptor μ1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemiaSynergistic Cytotoxic Effect of L-Asparaginase Combined with Decitabine as a Demethylating Agent in Pediatric T-ALL, with Specific Epigenetic Signature.Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells.Glutaminase activity determines cytotoxicity of L-asparaginases on most leukemia cell lines.Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells.Expression of asparagine synthetase predicts in vitro response to L-asparaginase in canine lymphoid cell lines.Asparaginase pharmacology: challenges still to be faced.DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.Asparagine levels in the bone marrow of patients with acute lymphoblastic leukemia during asparaginase therapy.Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency.Asparagine synthetase: Function, structure, and role in disease.CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway.Regulation of the ATF3 gene by a single promoter in response to amino acid availability and endoplasmic reticulum stress in human primary hepatocytes and hepatoma cells.
P2860
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P2860
Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Correlation between asparagina ...... hoblastic leukemia cell lines.
@en
type
label
Correlation between asparagina ...... hoblastic leukemia cell lines.
@en
prefLabel
Correlation between asparagina ...... hoblastic leukemia cell lines.
@en
P2093
P50
P356
P1476
Correlation between asparagina ...... hoblastic leukemia cell lines.
@en
P2093
Michael S Kilberg
P304
P356
10.1002/PBC.21213
P577
2008-02-01T00:00:00Z