Abrogation of MAPK and Akt signaling by AEE788 synergistically potentiates histone deacetylase inhibitor-induced apoptosis through reactive oxygen species generation.
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Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma cellsPreclinical evaluation of dual PI3K-mTOR inhibitors and histone deacetylase inhibitors in head and neck squamous cell carcinomaHDAC inhibition decreases the expression of EGFR in colorectal cancer cells.Histone Deacetylase Inhibitors: Advancing Therapeutic Strategies in Hematological and Solid Malignancies.MHC class II regulation by epigenetic agents and microRNAs.Antioxidants impair anti-tumoral effects of Vorinostat, but not anti-neoplastic effects of Vorinostat and caspase-8 downregulationMultitarget inhibitors derived from crosstalk mechanism involving VEGFR2.Schedule-dependent synergy of histone deacetylase inhibitors with DNA damaging agents in small cell lung cancerHistone deacetylase inhibitors: emerging mechanisms of resistance.An epigenetic vaccine model active in the prevention and treatment of melanomaPreclinical studies of novel targeted therapies.Dicer is regulated by cellular stresses and interferons.Targeting histone deacetylases for the treatment of diseaseHistone acetyltransferase PCAF up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling.Targeting tumor angiogenesis with histone deacetylase inhibitors.Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells.Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models.Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition.Synergistic action by multi-targeting compounds produces a potent compound combination for human NSCLC both in vitro and in vivo.Modulation of gene expression in ovarian cancer by active and repressive histone marks.Histone deacetylase inhibitors and cell death.Epigenetic drugs for cancer treatment and prevention: mechanisms of action.Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches.Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment.mTORC1 inhibition and ECM-cell adhesion-independent drug resistance via PI3K-AKT and PI3K-RAS-MAPK feedback loops.Critical analysis of simultaneous blockage of histone deacetylase and multiple receptor tyrosine kinase in the treatment of prostate cancer.Study of two tyrosine kinase inhibitors on growth and signal transduction in polycythemia vera.Oxidative stress and lipid peroxidation products in cancer progression and therapy.Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells.Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells.Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity.Panobinostat as Pan-deacetylase Inhibitor for the Treatment of Pancreatic Cancer: Recent Progress and Future Prospects.Synergistic anticancer effect of panobinostat and topoisomerase inhibitors through ROS generation and intrinsic apoptotic pathway induction in cervical cancer cells.
P2860
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P2860
Abrogation of MAPK and Akt signaling by AEE788 synergistically potentiates histone deacetylase inhibitor-induced apoptosis through reactive oxygen species generation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Abrogation of MAPK and Akt sig ...... ive oxygen species generation.
@en
type
label
Abrogation of MAPK and Akt sig ...... ive oxygen species generation.
@en
prefLabel
Abrogation of MAPK and Akt sig ...... ive oxygen species generation.
@en
P2093
P1476
Abrogation of MAPK and Akt sig ...... ive oxygen species generation.
@en
P2093
Alex A Adjei
Andrea McCollum
Bret B Friday
Chunrong Yu
Jin-Ping Lai
Peter Atadja
P304
P356
10.1158/1078-0432.CCR-06-1751
P407
P577
2007-02-01T00:00:00Z