Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells.
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Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1)HYAL1 overexpression is correlated with the malignant behavior of human breast cancerUpregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesisHyaluronan, Inflammation, and Breast Cancer ProgressionModeling vitamin D actions in triple negative/basal-like breast cancer.Orphan nuclear receptor HNF4G promotes bladder cancer growth and invasion through the regulation of the hyaluronan synthase 2 geneCD44-mediated adhesion to hyaluronic acid contributes to mechanosensing and invasive motilityA stable explant culture of HER2/neu invasive carcinoma supported by alpha-Smooth Muscle Actin expressing stromal cells to evaluate therapeutic agentsGraphical-model Based Multiple Testing under Dependence, with Applications to Genome-wide Association Studies.Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells.Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosisIn vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver.Breast tumor microenvironment: proteomics highlights the treatments targeting secretome.Inhibition of oesophageal squamous cell carcinoma progression by in vivo targeting of hyaluronan synthesis.Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44.Hyaluronan-CD44 interactions as potential targets for cancer therapy.4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer.Chronic UVR causes increased immunostaining of CD44 and accumulation of hyaluronan in mouse epidermis.Molecular characterization of kidney cancer: association of hyaluronic acid family with histological subtypes and metastasis.Hyaluronan synthase 2 overexpression is correlated with the tumorigenesis and metastasis of human breast cancer.The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activityEsophageal Squamous Cell Carcinoma Cells Modulate Chemokine Expression and Hyaluronan Synthesis in FibroblastsThe hyaluronan synthesis inhibitor 4-methylumbelliferone exhibits antitumor effects against mesenchymal-like canine mammary tumor cells.Loss of Glycogen Debranching Enzyme AGL Drives Bladder Tumor Growth via Induction of Hyaluronic Acid SynthesisInhibition of versican expression by siRNA facilitates tropoelastin synthesis and elastic fiber formation by human SK-LMS-1 leiomyosarcoma smooth muscle cells in vitro and in vivo.Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis.Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phalangeal joint patterning.Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation.Metastatic stem cells: sources, niches, and vital pathways.Hyaluronan metabolism in remodeling extracellular matrix: probes for imaging and therapy of breast cancer.Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer.Targeting hyaluronic acid family for cancer chemoprevention and therapy.Sugars in the microenvironment: the sticky problem of HA turnover in tumors.Antitumor effects of 4-methylumbelliferone, a hyaluronan synthesis inhibitor, on malignant peripheral nerve sheath tumor.Long noncoding RNA HAS2-AS1 mediates hypoxia-induced invasiveness of oral squamous cell carcinoma.No influence of exogenous hyaluronan on the behavior of human cancer cells or endothelial cell capillary formation.Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance.Antitumor effects of hyaluronan inhibition in desmoid tumors.Role of hyaluronan synthase 2 to promote CD44-dependent oral cavity squamous cell carcinoma progression.
P2860
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P2860
Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Silencing of hyaluronan syntha ...... invasive breast cancer cells.
@en
type
label
Silencing of hyaluronan syntha ...... invasive breast cancer cells.
@en
prefLabel
Silencing of hyaluronan syntha ...... invasive breast cancer cells.
@en
P2093
P2860
P356
P1476
Silencing of hyaluronan syntha ...... invasive breast cancer cells.
@en
P2093
Paraskevi Heldin
Tracey J Brown
Yuejuan Li
P2860
P304
P356
10.1002/IJC.22550
P577
2007-06-01T00:00:00Z