Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
about
Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exerciseThe Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motifSignaling effect of amyloid-beta(42) on the processing of AbetaPPCerebrovascular disease in ageing and Alzheimer's diseaseImpaired Aβ clearance: a potential link between atherosclerosis and Alzheimer's diseaseDeficiency of the copper chaperone for superoxide dismutase increases amyloid-β productionA functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylationThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disordersApoptogenic interactions of plasmalemmal type-1 VDAC and Aβ peptides via GxxxG motifs induce Alzheimer's disease - a basic model of apoptosis?Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer's disease cybrid cells.The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing miceThe relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin.Increased γ-secretase activity in idiopathic normal pressure hydrocephalus patients with β-amyloid pathology.Viable mouse gene ablations that robustly alter brain Aβ levels are rare.RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environmentGenetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect.Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons.Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease.Optical imaging in an Alzheimer's mouse model reveals amyloid-β-dependent vascular impairment.Predictors of the progression of dementia severity in brazilian patients with Alzheimer's disease and vascular dementia.Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer diseaseProteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's diseaseTranscriptional regulation of α1H T-type calcium channel under hypoxiaMutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions.Blood pressure and dementia - a comprehensive review.Melatonin and its agonist ramelteon in Alzheimer's disease: possible therapeutic value.Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor proteinDifferential regulation of BACE1 expression by oxidative and nitrosative signalsP2Y receptors in Alzheimer's disease.Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells.Matrix metalloproteinase (MMP)-9 induced by Wnt signaling increases the proliferation and migration of embryonic neural stem cells at low O2 levels.Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.Platelet-derived secreted amyloid-precursor protein-β as a marker for diagnosing Alzheimer's disease.
P2860
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P2860
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Hypoxia-inducible factor 1alph ...... n and beta-amyloid generation.
@en
type
label
Hypoxia-inducible factor 1alph ...... n and beta-amyloid generation.
@en
prefLabel
Hypoxia-inducible factor 1alph ...... n and beta-amyloid generation.
@en
P2093
P2860
P356
P1476
Hypoxia-inducible factor 1alph ...... n and beta-amyloid generation.
@en
P2093
Francesca-Fang Liao
Jiankun Cui
Ruishan Wang
Stuart A Lipton
Xian Zhang
Yun-wu Zhang
P2860
P304
10873-10880
P356
10.1074/JBC.M608856200
P407
P577
2007-02-15T00:00:00Z