Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle.

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description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

@zh-hk

2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Direct positive selection for ...... teriophage lambda lytic cycle.

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type

Item

label

Direct positive selection for ...... teriophage lambda lytic cycle.

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prefLabel

Direct positive selection for ...... teriophage lambda lytic cycle.

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P1476

Direct positive selection for ...... teriophage lambda lytic cycle.

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Grove JI

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Guise CP

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Hyde EI

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Searle PF

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P2860

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution

Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors.

Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity.

Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.

Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).

Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

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690-698

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scholarly article

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10.1038/SJ.GT.3302919

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2007-02-15T00:00:00Z

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6503286

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bacteriophage