Intestinal drug transporter expression and the impact of grapefruit juice in humans. - Wikidata - awgldk - TriplyDB

Intestinal drug transporter expression and the impact of grapefruit juice in humans.

Intestinal drug transporter expression and the impact of grapefruit juice in humans.

http://www.wikidata.org/entity/Q40184411

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Fruit juice inhibition of uptake transport: a new type of food-drug interaction Bile acid transporters Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies Role of solute carriers in response to anticancer drugs Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data.Integration of preclinical and clinical data with pharmacokinetic modeling and simulation to evaluate fexofenadine as a probe for hepatobiliary transport function.Gemfibrozil concentrations are significantly decreased in the presence of lopinavir-ritonavir Validation and application of a liquid chromatography-tandem mass spectrometric method for quantification of the drug transport probe fexofenadine in human plasma using 96-well filter plates.A modified grapefruit juice eliminates two compound classes as major mediators of the grapefruit juice-fexofenadine interaction: an in vitro-in vivo "connect"Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Cyanobacterial Toxins of the Laurentian Great Lakes, Their Toxicological Effects, and Numerical Limits in Drinking Water Central neurotoxicity in cancer chemotherapy: pharmacogenetic insights.Environmental and genetic factors affecting transport of imatinib by OATP1A2 Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations.Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity.Sotalol permeability in cultured-cell, rat intestine, and PAMPA system.Fingerprinting food: current technologies for the detection of food adulteration and contamination.Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1.Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways.Influence of dietary substances on intestinal drug metabolism and transport.Mechanisms and assessment of statin-related muscular adverse effects.Marginal increase of sunitinib exposure by grapefruit juice.Impact of OATP transporters on pharmacokinetics.The effect of grapefruit juice on drug disposition.Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney.Interactions of green tea catechins with organic anion-transporting polypeptides.Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren.PDZK1 and NHERF1 regulate the function of human organic anion transporting polypeptide 1A2 (OATP1A2) by modulating its subcellular trafficking and stability.Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae).Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells The expression and function of organic anion transporting polypeptides in normal tissues and in cancer Contribution of tumoral and host solute carriers to clinical drug response.Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid.Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP.Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.

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P2860

Intestinal drug transporter expression and the impact of grapefruit juice in humans.

http://www.wikidata.org/entity/Q40184411

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Intestinal drug transporter expression and the impact of grapefruit juice in humans.

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Bailey DG

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Dresser GK

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Glaeser H

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Schwarz UI

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P2860

Grapefruit juice-drug interactions

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

Interactions between grapefruit juice and cardiovascular drugs

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition.

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine.

The drug efflux-metabolism alliance: biochemical aspects.

Interaction of citrus juices with felodipine and nifedipine.

Importance of P-glycoprotein for drug disposition in humans.

MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.

Functional interaction of intestinal CYP3A4 and P-glycoprotein.

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