Enhancing specificity in the Janus kinases: a study on the thienopyridine JAK2 selective mechanism combined molecular dynamics simulation.

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Understanding the microscopic binding mechanism of hydroxylated and sulfated polybrominated diphenyl ethers with transthyretin by molecular docking, molecular dynamics simulations and binding free energy calculations.

P2860

Q30398895-FCBFD63D-C545-49FB-9A43-15275CC158EC

P2860

Enhancing specificity in the Janus kinases: a study on the thienopyridine JAK2 selective mechanism combined molecular dynamics simulation.

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http://www.wikidata.org/entity/Q40188503

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

2015年论文

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2015年论文

@zh-cn

name

Enhancing specificity in the J ...... molecular dynamics simulation.

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type

Item

label

Enhancing specificity in the J ...... molecular dynamics simulation.

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prefLabel

Enhancing specificity in the J ...... molecular dynamics simulation.

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P1476

Enhancing specificity in the J ...... molecular dynamics simulation.

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P2093

Jiao Jiao Li

http://www.w3.org/2001/XMLSchema#string

Jing Tu

http://www.w3.org/2001/XMLSchema#string

Peng Cheng

http://www.w3.org/2001/XMLSchema#string

Xiao Yun Zhang

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P2860

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase

The Protein Data Bank

Comparison of simple potential functions for simulating liquid water

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2

Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains

Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6

Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway

Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors

Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors

Comparison of multiple Amber force fields and development of improved protein backbone parameters

P304

575-587

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P31

scholarly article

P356

10.1039/C5MB00747J

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Hong Lin Zhai

P577

2015-12-21T00:00:00Z

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P698

26687880

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Enhancing specificity in the Janus kinases: a study on the thienopyridine JAK2 selective mechanism combined molecular dynamics simulation.

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P2860

P2860

Enhancing specificity in the Janus kinases: a study on the thienopyridine JAK2 selective mechanism combined molecular dynamics simulation.

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type

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P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698