Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2

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http://www.wikidata.org/entity/Q27644279
Advances in kinase inhibition: treating rheumatic diseases and beyond.Selective JAK inhibitors in development for rheumatoid arthritis.Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.Evaluation of WO-2013040863, WO-2013041042 and WO-2013043962. Selective JAK1 inhibitors based on a 3-aminopyrazole-4-carboxamide scaffold.Toward selective TYK2 inhibitors as therapeutic agents for the treatment of inflammatory diseases.Selective JAK inhibitors.Progress toward JAK1-selective inhibitors.Enhancing specificity in the Janus kinases: a study on the thienopyridine JAK2 selective mechanism combined molecular dynamics simulation.A probabilistic method to report predictions from a human liver microsomes stability QSAR model: a practical tool for drug discovery.Design and synthesis of tricyclic JAK3 inhibitors with picomolar affinities as novel molecular probes.Molecular modeling-driven approach for identification of Janus kinase 1 inhibitors through 3D-QSAR, docking and molecular dynamics simulations.
P2860

Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2

Item
http://www.wikidata.org/entity/Q27644279
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Identification of C-2 hydroxye ...... and high selectivity over JAK2
@ast
Identification of C-2 hydroxye ...... and high selectivity over JAK2
@en
Identification of C-2 hydroxye ...... and high selectivity over JAK2
@nl
type
label
Identification of C-2 hydroxye ...... and high selectivity over JAK2
@ast
Identification of C-2 hydroxye ...... and high selectivity over JAK2
@en
Identification of C-2 hydroxye ...... and high selectivity over JAK2
@nl
prefLabel
Identification of C-2 hydroxye ...... and high selectivity over JAK2
@ast
Identification of C-2 hydroxye ...... and high selectivity over JAK2
@en
Identification of C-2 hydroxye ...... and high selectivity over JAK2
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Identification of C-2 hydroxye ...... and high selectivity over JAK2
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698