An intersubunit interaction between S4-S5 linker and S6 is responsible for the slow off-gating component in Shaker K+ channels.
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Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channelCellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano-Ward syndromeCooperative activation of the T-type CaV3.2 channel: interaction between Domains II and III.Moving gating charges through the gating pore in a Kv channel voltage sensor.A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels.Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels.Properties of deactivation gating currents in Shaker channelsElucidating the molecular basis of action of a classic drug: guanidine compounds as inhibitors of voltage-gated potassium channels.Control of a final gating charge transition by a hydrophobic residue in the S2 segment of a K+ channel voltage sensor.Double mutant cycle analysis identified a critical leucine residue in the IIS4S5 linker for the activation of the Ca(V)2.3 calcium channel.Conservation analysis of residues in the S4-S5 linker and the terminal part of the S5-P-S6 pore modulus in Kv and HCN channels: flexible determinants for the electromechanical coupling.Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain.The Human Sodium-Glucose Cotransporter (hSGLT1) Is a Disulfide-Bridged Homodimer with a Re-Entrant C-Terminal LoopOpposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels.Coupling of voltage-sensors to the channel pore: a comparative viewMigration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivationReinitiation at non-canonical start codons leads to leak expression when incorporating unnatural amino acids.Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening.Tetrameric assembly of KvLm K+ channels with defined numbers of voltage sensors.Molecular mechanism for depolarization-induced modulation of Kv channel closure.A limited 4 Å radial displacement of the S4-S5 linker is sufficient for internal gate closing in Kv channels.Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization.Perspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels.Intra- and Intersubunit Dynamic Binding in Kv4.2 Channel Closed-State InactivationDynamics of internal pore opening in K(V) channels probed by a fluorescent unnatural amino acid.The pore of voltage-gated potassium ion channels is strained when closed.Decomposition of slide helix contributions to ATP-dependent inhibition of Kir6.2 channelsThe isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel.Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Voltage-dependent gating of HERG potassium channels.Mechanism of electromechanical coupling in voltage-gated potassium channels.Being flexible: the voltage-controllable activation gate of kv channels.Molecular biology and biophysical properties of ion channel gating pores.Mechanisms of activation of voltage-gated potassium channels.Voltage-clamp Fluorometry in Xenopus Oocytes Using Fluorescent Unnatural Amino Acids.Hysteresis in voltage-gated channelsComponents of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels.Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations.Do lipids show state-dependent affinity to the voltage-gated potassium channel KvAP?A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel.
P2860
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P2860
An intersubunit interaction between S4-S5 linker and S6 is responsible for the slow off-gating component in Shaker K+ channels.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
An intersubunit interaction be ...... mponent in Shaker K+ channels.
@en
type
label
An intersubunit interaction be ...... mponent in Shaker K+ channels.
@en
prefLabel
An intersubunit interaction be ...... mponent in Shaker K+ channels.
@en
P2860
P356
P1476
An intersubunit interaction be ...... mponent in Shaker K+ channels.
@en
P2093
Georges A Haddad
Zarah Batulan
P2860
P304
14005-14019
P356
10.1074/JBC.M109.097717
P407
P577
2010-03-04T00:00:00Z