Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe.
about
Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesisArbovirus high fidelity variant loses fitness in mosquitoes and miceCommon and unique features of viral RNA-dependent polymerasesViral quasispecies evolutionStructural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase.Counteracting Quasispecies Adaptability: Extinction of a Ribavirin-Resistant Virus Mutant by an Alternative Mutagenic TreatmentSequential structures provide insights into the fidelity of RNA replicationStructure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to RibavirinA Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-EscapeMutagenic Effects of Ribavirin on Hepatitis E Virus-Viral Extinction versus Selection of Fitness-Enhancing MutationsSelection for robustness in mutagenized RNA virusesPotential benefits of sequential inhibitor-mutagen treatments of RNA virus infectionsCell type mediated resistance of vesicular stomatitis virus and Sendai virus to ribavirinInhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymeraseCoronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeuticsSensitivity of a ribavirin resistant mutant of hepatitis C virus to other antiviral drugsTopology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection.Deletion mutants of VPg reveal new cytopathology determinants in a picornavirus.Attenuation of human enterovirus 71 high-replication-fidelity variants in AG129 miceMolecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.Exploring the fitness landscape of an RNA virus by using a universal barcode microarrayRationalizing the development of live attenuated virus vaccinesMutagenesis-mediated decrease of pathogenicity as a feature of the mutant spectrum of a viral population.Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures.Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases.Molecular dynamics simulations of viral RNA polymerases link conserved and correlated motions of functional elements to fidelityEffects of ribavirin on the replication and genetic stability of porcine reproductive and respiratory syndrome virusIsolation of fidelity variants of RNA viruses and characterization of virus mutation frequency.Lethal mutagenesis: targeting the mutator phenotype in cancer.Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivoMutational robustness of an RNA virus influences sensitivity to lethal mutagenesis.Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir.A Polymerase mechanism-based strategy for viral attenuation and vaccine development.Anti-foot-and-mouth disease virus effects of Chinese herbal kombucha in vivoThe Attenuation Phenotype of a Ribavirin-Resistant Porcine Reproductive and Respiratory Syndrome Virus Is Maintained during Sequential Passages in Pigs.Deep sequencing reveals mutagenic effects of ribavirin during monotherapy of hepatitis C virus genotype 1-infected patients.Hidden virulence determinants in a viral quasispecies in vivoTherapeutically targeting RNA viruses via lethal mutagenesis.Ribavirin-resistant variants of foot-and-mouth disease virus: the effect of restricted quasispecies diversity on viral virulence.Innate host barriers to viral trafficking and population diversity: lessons learned from poliovirus.
P2860
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P2860
Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Foot-and-mouth disease virus m ...... cations for error catastrophe.
@en
type
label
Foot-and-mouth disease virus m ...... cations for error catastrophe.
@en
prefLabel
Foot-and-mouth disease virus m ...... cations for error catastrophe.
@en
P2093
P2860
P356
P1433
P1476
Foot-and-mouth disease virus m ...... cations for error catastrophe.
@en
P2093
Antero Airaksinen
Claudia González-López
Macarena Sierra
Rubén Agudo
P2860
P304
P356
10.1128/JVI.01606-06
P407
P577
2006-12-06T00:00:00Z