PD-1 and CTLA4: Two checkpoints, one pathway? - Wikidata - awgldk - TriplyDB

PD-1 and CTLA4: Two checkpoints, one pathway?

PD-1 and CTLA4: Two checkpoints, one pathway?

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PD-1 and CTLA4: Two checkpoints, one pathway?

http://www.wikidata.org/entity/Q40204056

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2017 nî lūn-bûn

@nan

2017年の論文

@ja

2017年論文

@yue

2017年論文

@zh-hant

2017年論文

@zh-hk

2017年論文

@zh-mo

2017年論文

@zh-tw

2017年论文

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2017年论文

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2017年论文

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name

PD-1 and CTLA4: Two checkpoints, one pathway?

@en

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PD-1 and CTLA4: Two checkpoints, one pathway?

@en

prefLabel

PD-1 and CTLA4: Two checkpoints, one pathway?

@en

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SCIIMMUNOL.AAN3864

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Science immunology

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PD-1 and CTLA4: Two checkpoints, one pathway?

@en

P2093

Lucy S K Walker

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P2860

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.

Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.

Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.

The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.

Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes.

T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.

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scholarly article

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10.1126/SCIIMMUNOL.AAN3864

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11

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2

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P577

2017-05-01T00:00:00Z

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28529997

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5436606

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