Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide.
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Indoctrinating T cells to attack pathogens through homeschoolingHow much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'A New Twist in TCR Diversity Revealed by a Forbidden αβ TCRCrossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC MoleculesDistinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientationDifferent Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors † ‡Structures of native and affinity-enhanced WT1 epitopes bound to HLA-A0201: Implications for WT1-based cancer therapeuticsA highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHCA Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR ConformersA Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility LigandsEffect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand SpecificityThe molecular basis of TCR germline bias for MHC is surprisingly simpleThe effect of mutations on the alloreactive T cell receptor/peptide-MHC interface structure: a molecular dynamics study.Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens.The Goldilocks model for TCR-too much attraction might not be best for vaccine designAttenuated T cell responses to a high-potency ligand in vivo.High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics.Fast on-rates allow short dwell time ligands to activate T cells.Two mechanisms that account for major histocompatibility complex restriction of T cells.Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiationFunctional characterization of newly-discovered mutations in human SR-BIMolecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells.Evolving concepts of specificity in immune reactionsOn the logic of restrictive recognition of peptide by the T-cell antigen receptor.Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infectionT cell receptor specificity for major histocompatibility complex proteins.Characterization of antigenic variants of hepatitis C virus in immune evasion.Intramolecular polyspecificity in CD4 T-cell recognition of Ad-restricted epitopes of proteoglycan aggrecan.Mutagenesis of beryllium-specific TCRs suggests an unusual binding topology for antigen recognition.Survivin-specific T cell receptor targets tumor but not T cells.Evolutionarily conserved features contribute to αβ T cell receptor specificityPolyspecificity of T cell and B cell receptor recognition.TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines.A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis.Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable.Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.How the thymus designs antigen-specific and self-tolerant T cell receptor sequences.
P2860
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P2860
Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Interface-disrupting amino aci ...... atibility complex and peptide.
@en
type
label
Interface-disrupting amino aci ...... atibility complex and peptide.
@en
prefLabel
Interface-disrupting amino aci ...... atibility complex and peptide.
@en
P2860
P50
P356
P1433
P1476
Interface-disrupting amino aci ...... atibility complex and peptide.
@en
P2093
Eric S Huseby
Frances Crawford
P2860
P304
P356
10.1038/NI1401
P407
P577
2006-10-15T00:00:00Z