New insights on the use of desipramine as an inhibitor for acid ceramidase. - Wikidata - awgldk - TriplyDB

New insights on the use of desipramine as an inhibitor for acid ceramidase.

New insights on the use of desipramine as an inhibitor for acid ceramidase.

http://www.wikidata.org/entity/Q40244998

about

Identification of novel functional inhibitors of acid sphingomyelinase Hsp70.1 and related lysosomal factors for necrotic neuronal death Tamoxifen regulation of sphingolipid metabolism--Therapeutic implications Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection Dynamics of ceramide generation and metabolism in response to fenretinide--Diversity within and among leukemia Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction.Inhibition of SREBP1 sensitizes cells to death ligands.Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death.Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo.The contribution of lysosomotropism to autophagy perturbation.Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine.Ceramide--antiestrogen nanoliposomal combinations--novel impact of hormonal therapy in hormone-insensitive breast cancer.Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma.Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats.Ceramide in bacterial infections and cystic fibrosis.Roles and regulation of secretory and lysosomal acid sphingomyelinase.Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium.Endogenous ceramide contributes to the transcytosis of oxLDL across endothelial cells and promotes its subendothelial retention in vascular wall.Biological function of the cellular lipid BMP-BMP as a key activator for cholesterol sorting and membrane digestion.Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.Host-Directed Therapies for Tuberculosis.Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide.Acid sphingomyelinase promotes endothelial stress response in systemic inflammation and sepsis.Potent inhibition of Acid ceramidase by novel B-13 analogues.TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species.Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells.Sphingosine 1-phosphate activation of ERM contributes to vascular calcification.Structural basis for the activation of acid ceramidase.

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P2860

New insights on the use of desipramine as an inhibitor for acid ceramidase.

http://www.wikidata.org/entity/Q40244998

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

New insights on the use of desipramine as an inhibitor for acid ceramidase.

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New insights on the use of desipramine as an inhibitor for acid ceramidase.

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New insights on the use of desipramine as an inhibitor for acid ceramidase.

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J.FEBSLET.2006.07.071

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New insights on the use of desipramine as an inhibitor for acid ceramidase.

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Ahmed El-Zawahry

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Alicja Bielwaska

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Ayman Mahdy

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David H Holman

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James S Norris

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Joseph C Cheng

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Maristella Villani

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Saeed Elojeimy

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Xiang Liu

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Youssef Zeidan

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P2860

Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death

Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex

Human acid ceramidase is overexpressed but not mutated in prostate cancer

Purification, characterization, and biosynthesis of human acid ceramidase

Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry.

Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine.

Biologically active sphingolipids in cancer pathogenesis and treatment.

Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.

Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells.

Chloroquine-mediated radiosensitization is due to the destabilization of the lysosomal membrane and subsequent induction of cell death by necrosis.

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