Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells.
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Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitisA cell-based high-content screening assay reveals activators and inhibitors of cancer cell invasionTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsTherapeutic targeting of replicative immortalityThe role of Cdk5 in neuroendocrine thyroid cancerDifferential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesisGlutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activityRegulation of androgen receptor and prostate cancer growth by cyclin-dependent kinase 5Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cellsContribution of nestin positive esophageal squamous cancer cells on malignant proliferation, apoptosis, and poor prognosisCDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation.Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression.Identification of unique MEK-dependent genes in GNAQ mutant uveal melanoma involved in cell growth, tumor cell invasion, and MEK resistance.Quantitative imaging of epithelial cell scattering identifies specific inhibitors of cell motility and cell-cell dissociation.Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis.Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migrationTrisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors.Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8).Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signalingRNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5.The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - RoscovitineSurvivin is a potential mediator of prostate cancer metastasis.Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis.Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients.Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis.Computational identification and modeling of crosstalk between phosphorylation, O-β-glycosylation and methylation of FoxO3 and implications for cancer therapeutics.Cyclin-Dependent Kinase 5 (CDK5) Controls Melanoma Cell Motility, Invasiveness, and Metastatic Spread-Identification of a Promising Novel therapeutic target.Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomyAchaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway.Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-RasCyclin-dependent kinase inhibitors block leukocyte adhesion and migration.Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function.Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinomaRetinoic Acid Induces Apoptosis of Prostate Cancer DU145 Cells through Cdk5 OveractivationCdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasionInhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis.Low Expression of CDK5 and p27 Are Associated with Poor Prognosis in Patients with Gastric Cancer.
P2860
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P2860
Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Cyclin-dependent kinase 5 acti ...... tial of prostate cancer cells.
@en
type
label
Cyclin-dependent kinase 5 acti ...... tial of prostate cancer cells.
@en
prefLabel
Cyclin-dependent kinase 5 acti ...... tial of prostate cancer cells.
@en
P2093
P1433
P1476
Cyclin-dependent kinase 5 acti ...... tial of prostate cancer cells.
@en
P2093
Barry D Nelkin
Christopher J Strock
Douglas W Ball
Eric K Nakakura
G Steven Bova
John T Isaacs
Jong-In Park
P304
P356
10.1158/0008-5472.CAN-05-3048
P407
P577
2006-08-01T00:00:00Z