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Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemiaDiazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampus-dependent learningIn vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.Dual-modality gene reporter for in vivo imaging.Quantitative T(1rho) and magnetization transfer magnetic resonance imaging of acute cerebral ischemia in the rat.Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons.Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy.Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammationMetabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro.Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: correlation with cell density.Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepsy.Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.Long-term protective effect of atorvastatin in permanent focal cerebral ischemia.Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma.Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarateHyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoformExpression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regenerationEnhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosisTumour gene therapy monitoring using magnetic resonance imaging and spectroscopy.Development of Timd2 as a reporter gene for MRIDetection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent.Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatmentProduction of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors.Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy.Imaging pH with hyperpolarized 13C.Hyperpolarized 13C MRI and PET: in vivo tumor biochemistry.Hyperpolarized [U-(2) H, U-(13) C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells.MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment.Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1-(13) C]lactate and [1-(13) C]pyruvate.Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents.Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Mikko Kettunen
@ast
Mikko Kettunen
@en
Mikko Kettunen
@es
Mikko Kettunen
@nl
Mikko Kettunen
@sl
type
label
Mikko Kettunen
@ast
Mikko Kettunen
@en
Mikko Kettunen
@es
Mikko Kettunen
@nl
Mikko Kettunen
@sl
prefLabel
Mikko Kettunen
@ast
Mikko Kettunen
@en
Mikko Kettunen
@es
Mikko Kettunen
@nl
Mikko Kettunen
@sl
P1053
K-2299-2012
P106
P1153
7004862126
P21
P2456
P2798
P31
P3829
P496
0000-0002-2004-660X