The nucleotide pool is a significant target for oxidative stress.
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Oxidation of the guanine nucleotide pool underlies cell death by bactericidal antibioticsMycobacterial MazG safeguards genetic stability via housecleaning of 5-OH-dCTPHydroxyl radical oxidation of guanosine 5'-triphosphate (GTP): requirement for a GTP-Cu(II) complex.Possible benefits of tomato juice consumption: a pilot study on irradiated human lymphocytes from healthy donorsChemical and immunochemical detection of 8-halogenated deoxyguanosines at early stage inflammation.Tomato juice intake suppressed serum concentration of 8-oxodG after extensive physical activityProlonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1.Measurement of 7,8-dihydro-8-oxo-2'-deoxyguanosine metabolism in MCF-7 cells at low concentrations using accelerator mass spectrometry.Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular DamageThe MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells.Redox Activation of the Universally Conserved ATPase YchF by Thioredoxin 1.Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence.Sources of extracellular, oxidatively-modified DNA lesions: implications for their measurement in urine.Chronic Low Dose Rate Ionizing Radiation Exposure Induces Premature Senescence in Human Fibroblasts that Correlates with Up Regulation of Proteins Involved in Protection against Oxidative StressBattle against RNA oxidation: molecular mechanisms for reducing oxidized RNA to protect cells.Assays for urinary biomarkers of oxidatively damaged nucleic acids.Versatile physiological functions of the Nudix hydrolase family in Arabidopsis.MTH1, an 8-oxo-2'-deoxyguanosine triphosphatase, and MYH, a DNA glycosylase, cooperate to inhibit mutations induced by chronic exposure to oxidative stress of ionising radiation.Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence.Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant.Detection of extracellular 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker of oxidative damage in X-irradiated fibroblast cultures: optimization of analytical procedure.The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine.Biochemical properties of MutT2 proteins from Mycobacterium tuberculosis and M. smegmatis and their contrasting antimutator roles in Escherichia coliEvaluation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) adduct levels and DNA strand breaks in human peripheral blood lymphocytes exposed in vitro to polycyclic aromatic hydrocarbons with or without animal metabolic activation.Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairingDNA repair and the origins of urinary oxidized 2'-deoxyribonucleosides.Maladaptive DNA repair is the ultimate contributor to the death of trimethoprim-treated cells under aerobic and anaerobic conditions.Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.The m6A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide.TARGETED AND OFF-TARGET (BYSTANDER AND ABSCOPAL) EFFECTS OF RADIATION THERAPY: REDOX MECHANISMS AND RISK-BENEFIT ANALYSIS.Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors.Long-term exposure to diesel engine exhaust induces primary DNA damage: a population-based study.Antibacterial Efficacy of Silver Nanoparticles on Endometritis Caused by Prevotella melaninogenica and Arcanobacterum pyogenes in Dairy Cattle.MutT homolog 1 counteracts the effect of anti-neoplastic treatments in adult and pediatric glioblastoma cells.Serum 8-Oxo-dG as a Predictor of Sensitivity and Outcome of Radiotherapy and Chemotherapy of Upper Gastrointestinal Tumours.
P2860
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P2860
The nucleotide pool is a significant target for oxidative stress.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The nucleotide pool is a significant target for oxidative stress.
@en
type
label
The nucleotide pool is a significant target for oxidative stress.
@en
prefLabel
The nucleotide pool is a significant target for oxidative stress.
@en
P2093
P1476
The nucleotide pool is a significant target for oxidative stress.
@en
P2093
Lena Sjölander
Mats Harms-Ringdahl
Siamak Haghdoost
Stefan Czene
P304
P356
10.1016/J.FREERADBIOMED.2006.05.003
P577
2006-05-11T00:00:00Z