Actinobacillus actinomycetemcomitans leukotoxin requires lipid microdomains for target cell cytotoxicity.
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Bordetella adenylate cyclase toxin mobilizes its beta2 integrin receptor into lipid rafts to accomplish translocation across target cell membrane in two stepsRTX proteins: a highly diverse family secreted by a common mechanismAdenylate cyclase toxin promotes internalisation of integrins and raft components and decreases macrophage adhesion capacityStaphylococcal leukotoxins trigger free intracellular Ca(2+) rise in neurones, signalling through acidic stores and activation of store-operated channelsSelective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cellsProbing of Actinobacillus pleuropneumoniae ApxIIIA toxin-dependent cytotoxicity towards mammalian peripheral blood mononucleated cellsAnti-leukemia activity of a bacterial toxin with natural specificity for LFA-1 on white blood cells.Aggregatibacter actinomycetemcomitans leukotoxin (LtxA; Leukothera) induces cofilin dephosphorylation and actin depolymerization during killing of malignant monocytes.Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis.Mannheimia haemolytica leukotoxin binds to lipid rafts in bovine lymphoblastoid cells and is internalized in a dynamin-2- and clathrin-dependent manner.Aggregatibacter actinomycetemcomitans leukotoxin: from threat to therapyGangliosides block Aggregatibacter Actinomycetemcomitans leukotoxin (LtxA)-mediated hemolysisAggregatibacter actinomycetemcomitans leukotoxin: a powerful tool with capacity to cause imbalance in the host inflammatory responseLFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytesAggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for cytotoxicity.Human variability in innate immunity.Membrane association and destabilization by Aggregatibacter actinomycetemcomitans leukotoxin requires changes in secondary structuresAggregatibacter actinomycetemcomitans leukotoxin utilizes a cholesterol recognition/amino acid consensus site for membrane association.Pathogenicity of the highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans and its geographic dissemination and role in aggressive periodontitis.Use of a Cholesterol Recognition Amino Acid Consensus Peptide To Inhibit Binding of a Bacterial Toxin to Cholesterol.Inhibition of Bacterial Toxin Activity by the Nuclear Stain, DRAQ5™Brief heat treatment causes a structural change and enhances cytotoxicity of the Escherichia coli α-hemolysin.Leukotoxin (Leukothera®) targets active leukocyte function antigen-1 (LFA-1) protein and triggers a lysosomal mediated cell death pathway.Bordetella adenylate cyclase toxin promotes calcium entry into both CD11b+ and CD11b- cells through cAMP-dependent L-type-like calcium channels.Lipid raft-dependent uptake, signalling and intracellular fate of Porphyromonas gingivalis in mouse macrophages.Inhibition of LtxA toxicity by blocking cholesterol binding with peptides.Aggregatibacter actinomycetemcomitans leukotoxin cytotoxicity occurs through bilayer destabilization.Identification and characterization of hemolysin-like proteins similar to RTX toxin in Pasteurella pneumotropica.Rheumatoid arthritis and citrullination.Leukotoxin Is Delivered to Host Cells in an LFA-1-Indepdendent Manner When Associated with Outer Membrane VesiclesMembrane localization of the Repeats-in-Toxin (RTX) Leukotoxin (LtxA) produced by Aggregatibacter actinomycetemcomitansFunctional Consequences of Calcium Influx Promoted by Bacterial Pore-Forming Toxins
P2860
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P2860
Actinobacillus actinomycetemcomitans leukotoxin requires lipid microdomains for target cell cytotoxicity.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Actinobacillus actinomycetemco ...... for target cell cytotoxicity.
@en
type
label
Actinobacillus actinomycetemco ...... for target cell cytotoxicity.
@en
prefLabel
Actinobacillus actinomycetemco ...... for target cell cytotoxicity.
@en
P2093
P2860
P1476
Actinobacillus actinomycetemco ...... for target cell cytotoxicity.
@en
P2093
Cinthia M F Pacheco
Edward T Lally
Elliot V Hersh
Gerald Harrison
Irene R Kieba
Karen P Fong
Kathleen Boesze-Battaglia
Linda L Otis
Somesh Baranwal
P2860
P304
P356
10.1111/J.1462-5822.2006.00746.X
P577
2006-07-07T00:00:00Z