Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.
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Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyChemical Variations on the p53 Reactivation ThemeNovel strategies to target the ubiquitin proteasome system in multiple myelomaTargeting the ubiquitin pathway for cancer treatmentSmall molecule compounds targeting the p53 pathway: are we finally making progress?Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational ChangesEvaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 DomainDiscovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical DevelopmentDiscovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical DevelopmentThe p53 pathway as a target in cancer therapeutics: obstacles and promiseThe role of p53 in cancer drug resistance and targeted chemotherapyMolecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple MyelomaDesigning focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methodsPrediction of inhibitory activity of epidermal growth factor receptor inhibitors using grid search-projection pursuit regression methodInhibition of the MDM2 E3 Ligase induces apoptosis and autophagy in wild-type and mutant p53 models of multiple myeloma, and acts synergistically with ABT-737Probing Difference in Binding Modes of Inhibitors to MDMX by Molecular Dynamics Simulations and Different Free Energy MethodsEnergetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 InteractionA ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity.Therapeutic considerations for Mdm2: not just a one trick ponyDesign, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations.New targets for the treatment of follicular lymphoma.Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.Targeting p53 for Novel Anticancer Therapy.Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactionsMdm2 links genotoxic stress and metabolism to p53.Retinoid signaling regulates breast cancer stem cell differentiation.MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 functionMultiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia.A computational analysis of the binding model of MDM2 with inhibitors.From laptop to benchtop to bedside: structure-based drug design on protein targets.MDM2, MDMX and p53 in oncogenesis and cancer therapyNanosensing protein allostery using a bivalent mouse double minute two (MDM2) assayMI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapyDisruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.Regio- and stereoselective synthesis of spirooxindole 1'-nitro pyrrolizidines with five concurrent stereocenters under aqueous medium and their bioprospection using the zebrafish (Danio rerio) embryo model.MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53.Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.Wild type p53 reactivation: from lab bench to clinic.Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells.
P2860
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P2860
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Structure-based design of spir ...... s of the MDM2-p53 interaction.
@en
type
label
Structure-based design of spir ...... s of the MDM2-p53 interaction.
@en
prefLabel
Structure-based design of spir ...... s of the MDM2-p53 interaction.
@en
P2093
P50
P356
P1476
Structure-based design of spir ...... rs of the MDM2-p53 interaction
@en
P2093
Dongguang Qin
Guoping Wang
Jeanne Stuckey
Peter P Roller
Sanjeev Shangary
Shaomeng Wang
Zaneta Nikolovska-Coleska
P304
P356
10.1021/JM051122A
P407
P577
2006-06-01T00:00:00Z