Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.
about
Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based DesignEvaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 DomainStructure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 Å resolutionPeptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancerModeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable.Expanding the scope of oligo-pyrrolinone-pyrrolidines as protein-protein interface mimics.Towards vast libraries of scaffold-diverse, conformationally constrained oligomers.Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation.Reversible and noncompetitive inhibition of beta-tryptase by protein surface binding of tetravalent peptide ligands identified from a combinatorial split-mix library.In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport.Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactionsUniversal peptidomimetics.Minimalist and universal peptidomimetics.Structural mimicry of the α-helix in aqueous solution with an isoatomic α/β/γ-peptide backbone.Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactionsPotential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein.Discovery libraries targeting the major enzyme classes: the serine hydrolases.Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library.Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.Comprehensive peptidomimetic libraries targeting protein-protein interactions.Assembly of four diverse heterocyclic libraries enabled by Prins cyclization, Au-catalyzed enyne cycloisomerization, and automated amide synthesis.Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsEnhanced potency of bivalent small molecule gp41 inhibitors.Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactionsNMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41.Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions.Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction.Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative.Assessing helical protein interfaces for inhibitor design.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups.Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists.An α-helical peptidomimetic scaffold for dynamic combinatorial library formation.TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.Evaluating minimalist mimics by exploring key orientations on secondary structures (EKOS)Helix-mediated protein--protein interactions as targets for intervention using foldamers.
P2860
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P2860
Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Design, synthesis, and evaluat ...... protein-protein interactions.
@ast
Design, synthesis, and evaluat ...... protein-protein interactions.
@en
type
label
Design, synthesis, and evaluat ...... protein-protein interactions.
@ast
Design, synthesis, and evaluat ...... protein-protein interactions.
@en
prefLabel
Design, synthesis, and evaluat ...... protein-protein interactions.
@ast
Design, synthesis, and evaluat ...... protein-protein interactions.
@en
P2093
P2860
P50
P356
P1476
Design, synthesis, and evaluat ...... protein-protein interactions.
@en
P2093
Alex Shaginian
Dale L Boger
Inkyu Hwang
Jiandong Chen
Landon R Whitby
P2860
P304
P356
10.1021/JA810025G
P407
P577
2009-04-01T00:00:00Z