Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. - Wikidata - awgldk - TriplyDB

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes.

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes.

http://www.wikidata.org/entity/Q40275063

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The Alzheimer's amyloid-degrading peptidase, neprilysin: can we control it?Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1 Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP Overview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds Genetic heterogeneity in Alzheimer disease and implications for treatment strategies Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neurons Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories.APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements Structural and functional characterization of a novel FE65 protein product up-regulated in cognitively impaired FE65 knockout mice.Regulation of amyloid precursor protein processing by the Beclin 1 complex beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex What is the role of amyloid precursor protein dimerization?Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease.Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease The roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease.Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.Amyloid Precursor Protein Translation Is Regulated by a 3'UTR Guanine Quadruplex Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.X-linked mental retardation and epigenetics.Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase A TAG on to the neurogenic functions of APP

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P2860

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes.

http://www.wikidata.org/entity/Q40275063

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Regulated intramembrane proteo ...... sion of putative target genes.

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Regulated intramembrane proteo ...... sion of putative target genes.

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Regulated intramembrane proteo ...... sion of putative target genes.

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Alexandra Tolia

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Carmen Derks

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Katleen Craessaerts

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Lutgarde Serneels

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Mikhail A Filippov

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Sébastien S Hébert

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Ulrike Müller

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P2860

Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements

The amyloid-beta precursor protein: integrating structure with biological function

Alzheimer's disease: genes, proteins, and therapy

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Signalling downstream of activated mammalian Notch

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

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