Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase - Wikidata - awgldk - TriplyDB

Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase

Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase

http://www.wikidata.org/entity/Q37068079

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The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis Emerging roles of extracellular vesicles in the nervous system PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10 The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding.Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction.Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17.Proprotein convertases process Pmel17 during secretion.Mechanisms of protein delivery to melanosomes in pigment cells.The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma.[Biogenesis of melanosomes - the chessboard of pigmentation].SheddomeDB: the ectodomain shedding database for membrane-bound shed markers.The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation.Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils.PMEL: a pigment cell-specific model for functional amyloid formation The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB.BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.A mutation within the transmembrane domain of melanosomal protein Silver (Pmel17) changes lumenal fragment interactions.N-terminal domains elicit formation of functional Pmel17 amyloid fibrils Melanosomal formation of PMEL core amyloid is driven by aromatic residues.Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders.Fold modulating function: bacterial toxins to functional amyloids.Study of Exosomes Shed New Light on Physiology of Amyloidogenesis.Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms.Why are Functional Amyloids Non-Toxic in Humans?Transmembrane semaphorin5B is proteolytically processed into a repulsive neural guidance cue.Biogenesis of Melanosomes

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Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase

http://www.wikidata.org/entity/Q37068079

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on December 2008

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Formation of Pmel17 amyloid is ...... substrate for gamma-secretase

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Formation of Pmel17 amyloid is ...... substrate for gamma-secretase.

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type

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Formation of Pmel17 amyloid is ...... substrate for gamma-secretase

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Formation of Pmel17 amyloid is ...... substrate for gamma-secretase.

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Formation of Pmel17 Amyloid Is ...... Is a Substrate for γ-Secretase

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Formation of Pmel17 amyloid is ...... substrate for gamma-secretase

@en

Formation of Pmel17 amyloid is ...... substrate for gamma-secretase.

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P1433

Journal of Biological Chemistry

P1476

Formation of Pmel17 amyloid is ...... substrate for gamma-secretase

@en

P2093

Claudia Huelsmann

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Edward H Koo

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Hiroko Maruyama

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Sandra Baches

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Sascha Weggen

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P2860

A missense mutation in PMEL17 is associated with the Silver coat color in the horse

Pmel17 initiates premelanosome morphogenesis within multivesicular bodies

MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes

Cell-surface processing of pro-ADAMTS9 by furin

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes

Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

P304

2296-2306

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scholarly article

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10.1074/JBC.M808904200

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P433

4

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284

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Markus P Kummer

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2008-12-01T00:00:00Z

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19047044

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2629115

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