Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH(2)-terminal kinase/activator protein-1 signaling to regulate cell migration.
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IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumorsAntitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastomaCrosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud developmentStrategies and challenges in eliciting immunity to melanoma.Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expressionGrowth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.Insulin receptor substrates (IRSs) and breast tumorigenesis.Sustained c-Jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation.Membrane localization of insulin receptor substrate-2 (IRS-2) is associated with decreased overall survival in breast cancerIRS-2 G1057D polymorphism in Turkish patients with colorectal cancerInsulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers.Down-regulation of the oncogene cyclin D1 increases migratory capacity in breast cancer and is linked to unfavorable prognostic features.Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling.FOXC1 is a critical mediator of EGFR function in human basal-like breast cancer.Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways.Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.Association between IRS-2 G1057D polymorphism and risk of gastric cancer.M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells.Regulation of MAPKs by growth factors and receptor tyrosine kinasesEpidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1.Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.Insulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1.Integrin alpha chains exhibit distinct temporal and spatial localization patterns in epithelial cells of the Drosophila ovary.Expression and function of the insulin receptor substrate proteins in cancerTissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasionLack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancerCo-inhibition of EGFR and IGF1R synergistically impacts therapeutically on adrenocortical carcinoma.Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models.Hypoxia regulates insulin receptor substrate-2 expression to promote breast carcinoma cell survival and invasion.Epidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells.Anti-apoptotic role of EGF in HaCaT keratinocytes via a PPARbeta-dependent mechanism.Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas.Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation.Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors.Potential for functional redundancy in EGF and TGFalpha signaling in desmoid cells: a cDNA microarray analysis.MiR-23a-mediated migration/invasion is rescued by its target, IRS-1, in non-small cell lung cancer cells.YAP-TEAD signaling promotes basal cell carcinoma development via a c-JUN/AP1 axis
P2860
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P2860
Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH(2)-terminal kinase/activator protein-1 signaling to regulate cell migration.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Epidermal growth factor induce ...... ng to regulate cell migration.
@en
type
label
Epidermal growth factor induce ...... ng to regulate cell migration.
@en
prefLabel
Epidermal growth factor induce ...... ng to regulate cell migration.
@en
P2093
P1433
P1476
Epidermal growth factor induce ...... ng to regulate cell migration.
@en
P2093
Adrian V Lee
Heetae Kim
Hyun-Jung Kim
Isere Kuiatse
Powel H Brown
Xiaojiang Cui
P304
P356
10.1158/0008-5472.CAN-05-2858
P407
P577
2006-05-01T00:00:00Z