Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.
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PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitroCyclin-dependent kinase inhibitor therapy for hematologic malignanciesNew molecular targets in mantle cell lymphomaTherapeutic targeting of replicative immortalityTherapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.Mantle cell lymphoma in the era of precision medicine-diagnosis, biomarkers and therapeutic agentsCyclin D as a therapeutic target in cancerCyclin-dependent kinases 4 and 6 control tumor progression and direct glucose oxidation in the pentose cycleInhibitory effect of schisandrin B on gastric cancer cells in vitroIdentification of a human cyclin D1-derived peptide that induces human cytotoxic CD4 T cellsRecent advances of highly selective CDK4/6 inhibitors in breast cancerBiological and clinical significance of GSK-3beta in mantle cell lymphoma--an immunohistochemical study.Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer.Cyclin K and cyclin D1b are oncogenic in myeloma cells.The history and future of targeting cyclin-dependent kinases in cancer therapy.Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic eraCyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcomeMolecular targeted approaches in mantle cell lymphoma.Targeting cell cycle regulators in hematologic malignancies.Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression.Antiproliferative and apoptosis-inducing activity of schisandrin B against human glioma cells.A phase II, single-arm, open-label, multicenter study to evaluate the efficacy and safety of P276-00, a cyclin-dependent kinase inhibitor, in patients with relapsed or refractory mantle cell lymphomaProlonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.The impact of cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index.Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas.The cyclin D1b splice variant: an old oncogene learns new tricks.Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancerCDK4: A Key Player in the Cell Cycle, Development, and CancerMammalian interphase cdks: dispensable master regulators of the cell cycle.Novel therapeutic targets in mantle cell lymphoma.Cyclin d1 downregulation contributes to anticancer effect of isorhapontigenin on human bladder cancer cells.Phase I study of palbociclib, a cyclin-dependent kinase 4/6 inhibitor, in Japanese patientsClinicopathologic features of CDK6 translocation-associated B-cell lymphoproliferative disordersCo-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells.Nuclear cyclin D1: an oncogenic driver in human cancer.Targeting cell cycle and hormone receptor pathways in cancer.Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).Cyclin D1 in the Liver: Role of Noncanonical Signaling in Liver Steatosis and Hormone RegulationNovel potent pharmacological cyclin-dependent kinase inhibitors.Current and emerging new treatment strategies for mantle cell lymphoma.
P2860
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P2860
Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Mantle cell lymphoma cells exp ...... ition of CDK4 kinase activity.
@en
type
label
Mantle cell lymphoma cells exp ...... ition of CDK4 kinase activity.
@en
prefLabel
Mantle cell lymphoma cells exp ...... ition of CDK4 kinase activity.
@en
P2093
P2860
P1433
P1476
Mantle cell lymphoma cells exp ...... bition of CDK4 kinase activity
@en
P2093
Andrew B Gladden
Ewa Tomczak
J Alan Diehl
Mariusz A Wasik
Monika Kasprzycka
Peter Nowell
Raymond Lai
Samuel E Deprimo
Seth Sadis
Stephen Eck
P2860
P304
P356
10.1182/BLOOD-2006-04-016634
P407
P577
2006-05-11T00:00:00Z