Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer
about
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycleNew tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancerTherapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingThe RNA Splicing Response to DNA DamagePromise of personalized omics to precision medicineAlternative pre-mRNA splicing regulation in cancer: pathways and programs unhingedSingle enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer.Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene.Cyclin K and cyclin D1b are oncogenic in myeloma cells.Small-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma.Cell Cycle Deregulation in Ewing's Sarcoma PathogenesisEpigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.Global impact of RNA polymerase II elongation inhibition on alternative splicing regulationCyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcomeOncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanismsOncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing.Influence of CCND1 G870A polymorphism on the risk of HBV-related HCC and cyclin D1 splicing variant expression in Chinese population.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.Recent advances in the molecular pathogenesis of Ewing's sarcoma.EWSR1 binds the hepatitis C virus cis-acting replication element and is required for efficient viral replication.Oncogenic partnerships: EWS-FLI1 protein interactions initiate key pathways of Ewing's sarcoma.Transcript Isoform Variation Associated with Cytosine Modification in Human Lymphoblastoid Cell LinesLoss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish.Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis.Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines.A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.Insulin-like growth factor 1 receptor as a therapeutic target in ewing sarcoma: lack of consistent upregulation or recurrent mutation and a review of the clinical trial literature.Chromatin's thread to alternative splicing regulation.Ewing sarcoma protein: a key player in human cancerRNA splicing: a new player in the DNA damage responseRNA-binding proteins as molecular links between cancer and neurodegeneration.Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9.Knockdown of EWSR1/FLI1 expression alters the transcriptome of Ewing sarcoma cells in vitro.Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair.Female-specific rectal carcinogenesis in cyclin D1b transgenic mice.Downstream EWS/FLI1 - upstream Ewing's sarcomaKnocking down cyclin D1b inhibits breast cancer cell growth and suppresses tumor development in a breast cancer model.Cotranscriptional exon skipping in the genotoxic stress response.
P2860
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P2860
Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Alteration of cyclin D1 transc ...... c D1b splice isoform in cancer
@ast
Alteration of cyclin D1 transc ...... c D1b splice isoform in cancer
@en
type
label
Alteration of cyclin D1 transc ...... c D1b splice isoform in cancer
@ast
Alteration of cyclin D1 transc ...... c D1b splice isoform in cancer
@en
prefLabel
Alteration of cyclin D1 transc ...... c D1b splice isoform in cancer
@ast
Alteration of cyclin D1 transc ...... c D1b splice isoform in cancer
@en
P2093
P2860
P356
P1476
Alteration of cyclin D1 transc ...... c D1b splice isoform in cancer
@en
P2093
Danielle Bittencourt
Didier Auboeuf
Gabriel Sanchez
Jérôme Barbier
Karine Laud
P2860
P304
P356
10.1073/PNAS.0710748105
P407
P577
2008-04-14T00:00:00Z