Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides. - Wikidata - awgldk - TriplyDB

Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides.

Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides.

http://www.wikidata.org/entity/Q40287484

about

Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention Characterization of FKGK18 as inhibitor of group VIA Ca2+-independent phospholipase A2 (iPLA2β): candidate drug for preventing beta-cell apoptosis and diabetes Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships.Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.Inhibition of secreted phospholipases A₂ by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations.Phospholipase A2 superfamily members play divergent roles after spinal cord injury.Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics.Calcium-independent phospholipases A2 and their roles in biological processes and diseases.A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes.Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis.Synthesis of 2-oxoamides based on sulfonamide analogs of gamma-amino acids and their activity on phospholipase A2.2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry.Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease.New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2.Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases.Protective effect of cytosolic phospholipase A2 inhibition against inflammation and degeneration by promoting regulatory T cells in rats with experimental autoimmune encephalomyelitis.Phospholipase A2 inhibitors for the treatment of inflammatory diseases: a patent review (2010--present).2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2.2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity.2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A2 inhibitors.Fluorogenic probes to monitor cytosolic phospholipase A2 activity.ASB14780, an Orally Active Inhibitor of Group IVA Phospholipase A2, Is a Pharmacotherapeutic Candidate for Nonalcoholic Fatty Liver Disease.Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A (GIVA cPLA)

P2860

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P2860

Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides.

http://www.wikidata.org/entity/Q40287484

description

2006 nî lūn-bûn

@nan

2006年の論文

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2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

2006年论文

@zh

2006年论文

@zh-cn

name

Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides.

@en

type

label

Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides.

@en

prefLabel

Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides.

@en

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P1433

Journal of Medicinal Chemistry

P1476

Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides.

@en

P2093

Anna Peristeraki

http://www.w3.org/2001/XMLSchema#string

Daren Stephens

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Efrosini Barbayianni

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George Kokotos

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Jennifer Cooper

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Raymond A Deems

http://www.w3.org/2001/XMLSchema#string

Richard Harkewicz

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Violetta Constantinou-Kokotou

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P2860

Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine

Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism

The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad

Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity

Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2

Catalytic residues of group VIB calcium-independent phospholipase A2 (iPLA2gamma)

A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs

Bis-2-oxo amide triacylglycerol analogues: a novel class of potent human gastric lipase inhibitors.

Synthetic routes and lipase-inhibiting activity of long-chain alpha-keto amides.

Synthesis and study of a lipophilic alpha-keto amide inhibitor of pancreatic lipase.

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2821-2828

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scholarly article

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10.1021/JM050993H

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9

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49

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Edward A. Dennis

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2006-05-01T00:00:00Z

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7141435

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16640343

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2544624

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