Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP.
about
Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogenNEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer.Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogensMatrix metalloproteinases, T cell homing and beta-cell mass in type 1 diabetes.Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinaseOvarian furin (proprotein convertase subtilisin/kexin type3): expression, localization, and potential role in ovulation in the rat.Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.Matrix metalloproteinases in tumorigenesis: an evolving paradigm.Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.Molecular Validation of PACE4 as a Target in Prostate CancerProteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types.The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum.Fluid shear stress promotes proprotein convertase-dependent activation of MT1-MMP.The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis.Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase.Proteases as modulators of tumor-stromal interaction: primary tumors to bone metastases.Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cellsProprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity.T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells.Metastasis review: from bench to bedside.Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking.NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathwaySelective and potent furin inhibitors protect cells from anthrax without significant toxicityProteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.Prolonged circulation and increased tumor accumulation of liposomal vincristine in a mouse model of rhabdomyosarcoma.O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP).Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA.TGF-β-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche.Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity.
P2860
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P2860
Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Furin regulates the intracellu ...... ll surface-associated MT1-MMP.
@en
type
label
Furin regulates the intracellu ...... ll surface-associated MT1-MMP.
@en
prefLabel
Furin regulates the intracellu ...... ll surface-associated MT1-MMP.
@en
P2093
P356
P1433
P1476
Furin regulates the intracellu ...... ell surface-associated MT1-MMP
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1209572
P407
P577
2006-04-24T00:00:00Z
P5875
P6179
1023645775