Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome. - Wikidata - awgldk - TriplyDB

Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome.

Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome.

http://www.wikidata.org/entity/Q40289618

about

Megakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiation Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation.Megakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA-1, and P-TEFb.Transcriptional control of megakaryocyte development.Histone arginine methylation keeps RUNX1 target genes in an intermediate state.Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy.Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.Impairment of hepatic nuclear factor-4α binding to the Stim1 promoter contributes to high glucose-induced upregulation of STIM1 expression in glomerular mesangial cells RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.A novel mutation in the GATA1 gene associated with acute megakaryoblastic leukemia in a Korean Down syndrome patient.Constitutional aneuploidy and cancer predisposition.The impact of trisomy 21 on foetal haematopoiesis.Haematopoietic development and leukaemia in Down syndrome.A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells Global transcriptome and chromatin occupancy analysis reveal the short isoform of GATA1 is deficient for erythroid specification and gene expression.A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 and GATA1 bind the promoter of the ITGA2B gene RUNX1 and GATA1 bind the promoter of the GP1BA gene RUNX1 and GATA1 bind the promoter of the THBS1 gene RUNX1 and GATA1 bind the promoter of the MIR27A gene

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Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome.

http://www.wikidata.org/entity/Q40289618

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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Physical association of the pa ...... ia accompanying Down syndrome.

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Physical association of the pa ...... ia accompanying Down syndrome.

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Ito E

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Kanezaki R

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Kitabayashi I

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Takahashi Y

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Terui K

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Toki T

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Watanabe S

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Xu G

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P2860

A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction

The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1

Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform

Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment

RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation.

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.

Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development

GATA1 function, a paradigm for transcription factors in hematopoiesis

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1002-1008

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10.1038/SJ.LEU.2404223

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6

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20

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