Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.

Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.

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http://www.wikidata.org/entity/Q40291116

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MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs.

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Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.

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http://www.wikidata.org/entity/Q40291116

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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name

Preliminary investigation of 6 ...... nical models of schizophrenia.

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Preliminary investigation of 6 ...... nical models of schizophrenia.

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Preliminary investigation of 6 ...... nical models of schizophrenia.

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Preliminary investigation of 6 ...... nical models of schizophrenia.

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Carlos M Martínez-Viturro

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Carrie K Jones

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Claire Mackie

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Gregor J Macdonald

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Han Min Tong

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Hilde Lavreysen

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J Scott Daniels

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Jesús Alcázar

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José Manuel Bartolomé-Nebreda

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María Luz Martín-Martín

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P2860

Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes

Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications.

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.

Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolin

Targeting glutamate synapses in schizophrenia

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.

Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).

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429-434

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scholarly article

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10.1016/J.BMCL.2015.11.098

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English

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Colleen M. Niswender

Craig W. Lindsley

P Jeffrey Conn

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2015-11-28T00:00:00Z

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26684851

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schizophrenia

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4835042

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Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.

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P2860

P2860

Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.

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