Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. - Wikidata - awgldk - TriplyDB

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.

http://www.wikidata.org/entity/Q40291559

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Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability Negative regulation of the deacetylase SIRT1 by DBC1 Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis The histone deacetylase SIRT2 stabilizes Myc oncoproteins Effect of nitroxoline on angiogenesis and growth of human bladder cancer miR-34a repression of SIRT1 regulates apoptosis Sirtuin functions and modulation: from chemistry to the clinic Epigenetic associations in relation to cardiovascular prevention and therapeutics Mechanisms of epigenetic regulation of leukemia onset and progression P53/microRNA-34-induced metabolic regulation: new opportunities in anticancer therapy Sirtuins in epigenetic regulation High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer Sirtuin deacylases: a molecular link between metabolism and immunity The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease SIRT3 and cancer: tumor promoter or suppressor?Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells Emerging Roles of SIRT1 in Cancer Drug Resistance Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation Mammalian sirtuins: biological insights and disease relevance Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5 Rejuvenating sirtuins: the rise of a new family of cancer drug targets Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.Sirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2.Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells.How does SIRT1 affect metabolism, senescence and cancer?SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling Structure-based development of novel sirtuin inhibitors.Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.Identification and characterization of novel sirtuin inhibitor scaffolds Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors.Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression.Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions.SIRT1 and p53, effect on cancer, senescence and beyond.Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities.SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.

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P2860

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.

http://www.wikidata.org/entity/Q40291559

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Antitumor activity of a small- ...... formation regulator 2 enzymes.

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type

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Antitumor activity of a small- ...... formation regulator 2 enzymes.

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Antitumor activity of a small- ...... formation regulator 2 enzymes.

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0008-5472.CAN-05-3617

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Cancer Research

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Antitumor activity of a small- ...... formation regulator 2 enzymes.

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P2093

Aaron D Schuler

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Antonio Bedalov

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Birgit Heltweg

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Hongzhe Li

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Jeff Posakony

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Julian A Simon

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Ramya Kollipara

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Ronald A Depinho

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Sondra Goehle

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Tonibelle Gatbonton

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4368-4377

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scholarly article

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10.1158/0008-5472.CAN-05-3617

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8

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66

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2006-04-01T00:00:00Z

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7161011

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16618762

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