Rational design of the microtubule-targeting anti-breast cancer drug EM015.
about
Tubulin-interactive natural products as anticancer agentsPotent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogsSuprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilizationA novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering.Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach.Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathwayAntitumor activity of Noscapine in combination with Doxorubicin in triple negative breast cancer.Induction of reactive oxygen species-mediated autophagy by a novel microtubule-modulating agent.A novel microtubule-modulating agent induces mitochondrially driven caspase-dependent apoptosis via mitotic checkpoint activation in human prostate cancer cells.Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor.Non-addictive opium alkaloids selectively induce apoptosis in cancer cells compared to normal cells.Drugs that target dynamic microtubules: a new molecular perspectiveSynergistic antimicrotubule therapy for prostate cancerSecond generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluationMolecular cycloencapsulation augments solubility and improves therapeutic index of brominated noscapine in prostate cancer cellsA novel microtubule-modulating agent EM011 inhibits angiogenesis by repressing the HIF-1α axis and disrupting cell polarity and migrationAntiangiogenic effects of noscapine enhance radioresponse for GL261 tumors.Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics9-bromonoscapine-induced mitotic arrest of cigarette smoke condensate-transformed breast epithelial cells.EM011 activates a survivin-dependent apoptotic program in human non-small cell lung cancer cellsDetermination of factors controlling the particle size and entrapment efficiency of noscapine in PEG/PLA nanoparticles using artificial neural networks.
P2860
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P2860
Rational design of the microtubule-targeting anti-breast cancer drug EM015.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Rational design of the microtubule-targeting anti-breast cancer drug EM015.
@en
type
label
Rational design of the microtubule-targeting anti-breast cancer drug EM015.
@en
prefLabel
Rational design of the microtubule-targeting anti-breast cancer drug EM015.
@en
P2093
P1433
P1476
Rational design of the microtubule-targeting anti-breast cancer drug EM015
@en
P2093
Amr Ghaleb
Binfei Zhou
Dulal Panda
Harish C Joshi
James H Nettles
Meenakshi Gupta
Ramesh Chandra
Ritu Aneja
P304
P356
10.1158/0008-5472.CAN-05-2962
P407
P50
P577
2006-04-01T00:00:00Z