Structural bioinformatics-based design of selective, irreversible kinase inhibitors. - Wikidata - awgldk - TriplyDB

Structural bioinformatics-based design of selective, irreversible kinase inhibitors.

Structural bioinformatics-based design of selective, irreversible kinase inhibitors.

http://www.wikidata.org/entity/Q40307105

about

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib The chemical biology of protein phosphorylation Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor Beyond picomolar affinities: quantitative aspects of noncovalent and covalent binding of drugs to proteins Electrophilic affibodies forming covalent bonds to protein targets The selectivity of protein kinase inhibitors: a further update Molecular Targeting of ERKs/RSK2 Signaling Axis in Cancer Prevention Ca(2+) signaling in the myocardium by (redox) regulation of PKA/CaMKII RSK isoforms in cancer cell invasion and metastasis Programmed cell death in Leishmania: biochemical evidence and role in parasite infectivity Developing irreversible inhibitors of the protein kinase cysteinome Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase Chemical genetic strategy for targeting protein kinases based on covalent complementarity Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities Discovery of Potent and Selective Covalent Inhibitors of JNK Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer RSK3: A regulator of pathological cardiac remodeling Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization Covalent docking of large libraries for the discovery of chemical probes betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis Chemical probes that competitively and selectively inhibit Stat3 activation The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer.Pseudokinases: update on their functions and evaluation as new drug targets.PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.Activation of p90 ribosomal S6 kinase by ORF45 of Kaposi's sarcoma-associated herpesvirus and its role in viral lytic replication RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.Recruitment and activation of RSK2 by HIV-1 Tat Synthesis of a resorcylic acid lactone (RAL) library using fluorous-mixture synthesis and profile of its selectivity against a panel of kinases.

P2860

Q24293101-C1085233-69D3-4F8E-B73E-1C03827593B2 Q24610904-754CDF27-ABA2-4409-986B-9F9B2D20F6F1 Q24620636-BFD79D18-732E-46B9-8306-CF5E2FF18C7F Q24632768-AF9E0FF0-718D-499E-B850-55668B3E9BF9 Q24633214-C30A6132-8F6B-460D-84C7-1B83ADAC2A89 Q24646341-74550826-1A80-4D0C-B35B-167C13FB8777 Q24649147-9A742AAF-BC3E-4E86-BD94-3C9161A805FE Q24651974-CCB96DD6-5431-4957-918F-4245BAB82787 Q24654622-50922C40-D5F1-40F7-8A4E-9530E75DA435 Q26782527-BD3936DA-687E-455F-94E3-3B25186FCEB7 Q26796230-E94054E1-870D-4674-9A47-E0929BBA66C6 Q26827485-8FD4459B-176B-403B-BAF1-E281B7361D0D Q27025959-FD3DA118-786C-4824-AF72-4C6C1454DD65 Q27027983-828509E4-ED23-4BE1-B286-D444BCABD62E Q27652488-4185C139-55E0-421E-90DB-18E24011BA06 Q27652698-E3F9E394-F4D1-4F9A-9BF6-85019F8A58FB Q27661190-114B52B6-7748-4214-9A41-9B1F8D41E9D4 Q27666106-1F8B0CD5-A678-4418-86E0-40AF7B8ABCC6 Q27667351-71AD9E95-670D-4F90-9EE5-1ADCC8D0507B Q27670889-163AB572-F2E2-43C6-B044-CA6B6F1D7CE6 Q27671824-B7C0FA2D-5D1C-41DB-9A9A-C01B38511A49 Q27674057-91E62733-0D7E-45A0-B7F9-AA1DFC4F093B Q27675842-3D06BDEC-D4FB-4154-9DCD-A72CFDC9BCC8 Q27676927-C38D01CA-6E68-4170-A920-83489D3EFE8B Q27678280-DED2E62F-28AC-465F-AE53-9BF6D077A2CF Q28077322-8A3F87CB-69F3-4600-B609-9F0367A4B322 Q28086916-80AE2F49-AA54-4F4D-952C-9D59D6BAE0D7 Q28114321-82940207-B223-4B58-B4AB-DA5A3303C6C6 Q28250319-0532CC34-DB25-4DF6-A170-6863D5CBA769 Q28306984-FF6FE901-CF00-4CF3-A6F0-63D587916FF0 Q28475010-12F37531-195A-4C38-A3F3-184CF9C5B992 Q28834261-EC82451D-01F3-44FD-BC55-1BC778BEE2A9 Q30275521-EA08B16B-FDB7-4DB7-AEEA-7256745879FA Q30397636-D5C80FE1-69E7-4D7D-9DFA-23EE1D29A7D1 Q30417536-48FEB117-DA47-4FE8-AEC3-070727B1F393 Q30437044-AFED5869-327D-4140-BC24-E5B52F7057DD Q30441657-A9ECEE21-E9E0-44E2-AFE9-D6C8BD177322 Q30547051-FF299FED-C40E-483E-B5F6-236619B7F103 Q33269333-44991C5D-A7F9-475B-BEBA-77CB91208E10 Q33509846-C967FB8F-6DDB-4835-B958-535AA0FC78DD

P2860

Structural bioinformatics-based design of selective, irreversible kinase inhibitors.

http://www.wikidata.org/entity/Q40307105

description

2005 nî lūn-bûn

@nan

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

2005年论文

@zh

2005年论文

@zh-cn

name

Structural bioinformatics-based design of selective, irreversible kinase inhibitors.

@en

type

label

Structural bioinformatics-based design of selective, irreversible kinase inhibitors.

@en

prefLabel

Structural bioinformatics-based design of selective, irreversible kinase inhibitors.

@en

P1433

Q40307105-9C68C741-2F46-445C-B8C1-B9F0E0D63FDC

P1476

Q40307105-51A87354-5250-4352-84EC-A33F1F77ABC9

P2093

Q40307105-1FB1A99B-C696-43FC-8740-7AADEFC186C0

Q40307105-3FC73DDF-2205-4A86-AB6E-A147C06F90FD

Q40307105-95E82017-3334-4539-A462-137F936DEFF8

Q40307105-D2FA15F4-998C-48CD-B4E6-191B4E0ED588

P2860

Q40307105-0496FE48-B358-49CA-99CF-AFBFD7BD5AE7

Q40307105-10304863-9F5E-41B7-876C-41657F716D4D

Q40307105-18741CF6-C844-4F84-A0AD-0F56BDCAAD8F

Q40307105-1A547087-B42D-4A13-B2E6-6DC27266ED30

Q40307105-2F86934F-0F91-4A87-AEF0-BDCB92CEEF71

Q40307105-35A3FC1D-5BE5-4681-9198-E2E86789B5F3

Q40307105-7F81B1D0-4FB9-48AD-B05B-6EE0665972F5

Q40307105-855077D5-80F3-4AFB-ABBA-4345C3E52F88

Q40307105-8CE55589-4CA2-422F-9944-75E7C5665DBC

Q40307105-A7920BE4-79E2-4073-BB22-0C56799303C7

P304

Q40307105-78573237-9B6E-4830-8EDC-8B26C3C474D7

P31

Q40307105-C05E9B0B-FE54-45BA-8262-99902FCDA5CE

P356

Q40307105-E62D02B4-20B5-49D2-AAF6-87E79BED5C7E

P407

Q40307105-D9402F97-C530-43E2-ABA7-DCAB5F05D1FB

P433

Q40307105-BDF19088-81CD-4D59-8F81-A1A97B23ACF9

P478

Q40307105-B4E926D4-0C7C-4F5B-9BA0-FD40C6B2A817

P577

Q40307105-D980FAE2-B60A-41A8-A6E6-04087FDD42FB

P5875

Q40307105-08A169AA-973F-47C7-91B8-358058033969

P698

Q40307105-098254FB-4DCC-42B3-81C6-C317A8298C75

P921

Q40307105-2896B2B3-9BFB-4D93-B30E-971763611FE6

P932

Q40307105-5461D0F4-A60E-4F9A-AE18-D87D95D2CF72

P356

P1433

P1476

Structural bioinformatics-based design of selective, irreversible kinase inhibitors.

@en

P2093

Chao Zhang

http://www.w3.org/2001/XMLSchema#string

Jack Taunton

http://www.w3.org/2001/XMLSchema#string

Kevan M Shokat

http://www.w3.org/2001/XMLSchema#string

Michael S Cohen

http://www.w3.org/2001/XMLSchema#string

P2860

MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

The protein kinase complement of the human genome

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

P304

1318-1321

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1126/SCIENCE1108367

http://www.w3.org/2001/XMLSchema#string

P407

P433

5726

http://www.w3.org/2001/XMLSchema#string

P478

308

http://www.w3.org/2001/XMLSchema#string

P577

2005-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7821830

http://www.w3.org/2001/XMLSchema#string

P698

15919995

http://www.w3.org/2001/XMLSchema#string

P921

P932

3641834

http://www.w3.org/2001/XMLSchema#string