Inhibition of phosphatidylinositol 3-kinase increases efficacy of cisplatin in in vivo ovarian cancer models.
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Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasisRole of Akt signaling in resistance to DNA-targeted therapyChemoresistance and targeted therapies in ovarian and endometrial cancersConditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosisAn integrative approach to identifying cancer chemoresistance-associated pathwaysSignificance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy.CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion.Cellular responses to Cisplatin-induced DNA damage.Cisplatin in cancer therapy: molecular mechanisms of actionLipoplatin formulation review article.Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin‑resistant ovarian cancer.Expression of PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis.Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancer.Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma.Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the OvaryEstrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regressionFucoxanthin enhances cisplatin-induced cytotoxicity via NFκB-mediated pathway and downregulates DNA repair gene expression in human hepatoma HepG2 cells.Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.PI3 kinase/AKT pathway as a therapeutic target in multiple myeloma.Rapamycin by itself and additively in combination with carboplatin inhibits the growth of ovarian cancer cellsWilms' tumour suppressor gene 1 (WT1) is involved in the carcinogenesis of Lung cancer through interaction with PI3K/Akt pathway.mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary.FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cellsTherapeutic targets and new directions for antibodies developed for ovarian cancer.Phosphatidylinositol 3-kinase inhibition restores Ca2+ release defects and prolongs survival in myotubularin-deficient mice.Cisplatin associated with LY294002 increases cytotoxicity and induces changes in transcript profiles of glioblastoma cells.The effects of silencing of PI3K p85α on 5-FU-induced colorectal cancer cells apoptosis.Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells.The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells.PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathwaysModulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cells.New Insights into mTOR Signal Pathways in Ovarian-Related Diseases: Polycystic Ovary Syndrome and Ovarian CancerCisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effectsActivation of estrogen receptor α by estradiol and cisplatin induces platinum-resistance in ovarian cancer cells.Everolimus following 5-aza-2-deoxycytidine is a promising therapy in paclitaxel-resistant clear cell carcinoma of the ovary.Combination of intensity modulated radiotherapy followed treatment with p38 MAPK activation inhibitor inhibits the proliferation of MCF-7 breast cancer cells.
P2860
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P2860
Inhibition of phosphatidylinositol 3-kinase increases efficacy of cisplatin in in vivo ovarian cancer models.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Inhibition of phosphatidylinos ...... in vivo ovarian cancer models.
@en
type
label
Inhibition of phosphatidylinos ...... in vivo ovarian cancer models.
@en
prefLabel
Inhibition of phosphatidylinos ...... in vivo ovarian cancer models.
@en
P2093
P356
P1433
P1476
Inhibition of phosphatidylinos ...... in vivo ovarian cancer models.
@en
P2093
Hideki Igarashi
Hirohisa Kurachi
Ishida Gabriela Mirei
Jun Kawagoe
Kazuhiro Takahashi
Keiichi Tasaka
Maki Saitoh
Masahide Ohmichi
Masakazu Doshida
P304
P356
10.1210/EN.2005-1450
P407
P577
2006-01-05T00:00:00Z